Evaluation of Thalamus Area In Essential Tremor Patients With Proton Magnetik Resonance Spectroscopy
Adile Ozkan1, Fatma Candan2, Nihal Işık6, İlknur Aydın Cantürk2, Semra Arı3, Özgür Öztop Çakmak4, Tunahan Ayaz5
1Department Of Neurology, Faculty Of Medicine, Çanakkale 18 Mart University, Çanakkale, Turkey
2Department Of Neurology, Faculty Of Medicine, Medeniyet University Goztepe Education And Training Hospital, Istanbul, Turkey
3Department Of Neurology, Eskisehir Yunus Emre State Hospital, Eskisehir, Turkey (formerly, Goztepe Education And Training Hospital)
4Department Of Neurology, Faculty Of Medicine, Karabuk University,karabuk State Hospital, Karabuk, Turkey, (formerly, Goztepe Education And Training Hospital)
5Department Of Radiology, Faculty Of Medicine, Medeniyet University Goztepe Education And Training Hospital, Istanbul, Turkey
6Department Of Neurology, Faculty Of Medicine,bahcesehir University, Medikal Park Hospital,ıstanbul, Turkey
Keywords: Essential Tremor, Magnetic Resonance Spectroscopy, Thalamus
Abstract
INTRODUCTION: Although Essential tremor (ET) is the most common movement disorder, its pathogenesis is poorly understood. It is asserted that ventral intermediate nucleus (VIM) of thalamus is important in pathophysiology
METHODS: Previous study was aimed to evaluate N- acetyl L- Aspartate (NAA), choline (cho) and creatinine (Cr) values of 16 control cases and 42 ET patients diagnosed via proton magnetic resonance spectroscopy (H1-MRS) on VIM of talamus.
RESULTS: Mean NAA/Cr and NAA/Cho values of thalamus vim nucleus region in ET patients was statistically significantly lower than control group (respectively p=0.001; p=0.005). No significant relation was found between NAA/Cr, NAA/Cho values and age, family history, disease duration, tremor severity, dominant extremity localization of tremor and history of drug use of ET patients (p>0.05).
DISCUSSION AND CONCLUSION: Low NAA values in thalamus region of ET patients indicate neuron loss and cell death. Neuron loss in thalamus region that was asserted to play part in the pathophysiology of the patient may be an indicator for ET being a neurodegenerative disease.