Anticonvulsive Effect Of Mk-801 On Experimental Epileptic Model Induced By Kainic Acid In Rats | 1995, Volume 1 - Issue 4

İbrahim BORA¹, Oya ULUSAN², Mustafa BAKAR¹, Sibel GÜRÜN³, Mehmet ZARİFOĞLU¹, Faruk TURAN¹, İsmail Hakkı ULUS³, Erhan OĞUL¹

¹Uludağ Üniversitesi Tıp Fakültesi Nöroloji AD, Bursa
²Uludağ Üniversitesi Tıp Fakültesi Nöroşirurji AD, Bursa
³Uludağ Üniversitesi Tıp Fakültesi Farmakoloji AD, Bursa

Keywords: Experimental epilepsy, Kainic acid, MK-801.

Abstract

Synaptic transmission in the central nervous system ise supplied by chemical agents known as neurotransmitters. Kainic acid is a strong neuroexcitatory agent in brain which increase releases excitatory amino acids such as glutamate and aspartate. MK-801 is an anticonvulsant agent which reduces the effects of excitatory amino acids. Our aim was to investigate antiepileptic effects of MK-801 on seizures induced by kainic acid. In this study 45 rats were divided into three groups. Kainic acid wase given in the hipocampus. The first group was given kainic acid+saline, the second group was given kainic acid+MK-801 (as intraperitoneal) and the third group was served as the control. EEG recording and clinical seizure observation had done before and after these procedures and all scores were recorded. In the study and control groups it was establis hed statistically important differences between seizure starting period, clinical seizures and EEG scores. In this study, we concluded that MK-801 is moderately effective on clinical and electrbphysiolgicseizure activities induced by kainic acid in rats.