Clinical And Electropbysiologic Effects Of Atropine And Diazepam On Experımental Epilepsy Induced By Lithıum-Pilocarpine | 1995, Volume 1 - Issue 4

İbrahim BORA¹, Suat ÇELİK², Mustafa BAKAR¹, Sibel GÜRÜN³, Sadık SADIKOĞLU¹, Faruk TURAN¹, Mehmet ZARİFOĞLU¹, Çiğdem UÇKUNKAYA⁴, İsmail Hakkı ULUS³, Erhan OĞUL¹

¹Uludağ Üniversitesi Tıp Fakültesi Nöroloji AD, Bursa
²Uludağ Üniversitesi Tıp Fakültesi Nöroşirurji AD, Bursa
³Uludağ Üniversitesi Tıp Fakültesi Farmakoloji AD, Bursa
⁴Bursa Devlet Hastanesi

Keywords: Atropine, Experimental epilepsy, diazepam, lithium-pilocarpine, status epilepticus.

Abstract

In this study status epilepticus was induced in rats by administration of lithium chloridefollowed 24 hours later by injection of pilocarpine. Administration of atropine which a ismuscarinic-cholinergic receptor antagonist, before pilocarpine arrested generalised statusepilepticus, except limbic seizures. EEG displayed clear improvement. Administration ofdiazepam prior to pilocarpine blocked seizure and EEG activity. The results of this studysuggest that cholinergic mechanisms play an important role in lithium pilaocarpineepileptogenesis