Plasma Homocystein, Vitamin B12, Folate, Protein C And S Levels in Stroke Population At Acute Stage | 2003, Volume 9 - Issue 1

M. Fazıl GENÇ¹, Sibel KARŞIDAĞ², Feriha ÖZER³, Yasemin DÖVENTAŞ⁴, Macit KOLDAŞ⁵

¹Haseki Eğitim ve Araştırma Hastanesi Nöroloji Kliniği
²Haseki Eğitim ve Araştırma Hastanesi Nöroloji Kliniği Şef Yardımcısı
³Haseki Eğitim ve Araştırma Hastanesi Nöroloji Klinik Şefi
⁴Haseki Eğitim ve Araştırma Hastanesi Biyokimya Kliniği
⁵Haseki Eğitim ve Araştırma Hastanesi Biyokimya Klinik Şefi

Keywords: stroke, homocystein, folate, vitamin B12, protein C, protein S

Abstract

Currently, there had been so many studies about frequency of hyperhomocysteinemiain cerebrovascular disease. This study confirms this observation. Plasma homocysteine concentration was significantly increased in stroke group than the healthy control group (Patient group: 19.29.4, Control group: 154, p=0.006). In patient group, plasma folate level, protein C and S levels were significantly lower than the control group but serumvitamin B 12 level was not found different from control group. Hyperhomocysteinemia was present in 20 of 96 patient with stroke (21 %). Homocysteine concentration correlated the values for blood folate and plasma creatinine level.