Effect Of Hypothermia on Mortality in Patients Presented with Acute Cerebrovascular Disease

Abstract

Objective: Body temperature is critically important in influencing outcome of neuronal injury resulting from stroke. Mild to moderate decrements in brain temperature have been shown to decrease post ischemic neuronal necrosis. In this study we investigated the body temperature on short term mortality of the patients with acute cerebrovascular disease. Material and Methods: Two hundred five patients administrated with acuteserebrovascular disease were included in this study. Body temperature was classified as hypothermia (<36.5°C) and normothermia-hyperthermia (36.5°C). We studied leukocyte count, C-reactive protein, sedimentation and other routines of the patients. Assosiation between the body temperature and the mortality of the patients was examined. Results: There is not a difference between the patients for demographic chracteristics. 88 of the 113 hypothermic patients discharged from hospital while 25 of them died. 31 of 92 normothermic-hyperthermic patients died. There is not a statisticaly difference between two groups (p>0.05). Conclusions: Lowering body temperature through hypothermic therapy to be a strong neuroprotective measure and elevation of body temperature has been shown to result in more extensive brain damage have been demonstrated inanimal stroke models. However, we didn't find an effect of hypothermia on short time mortality.