Antiphospholipid Syndrome: A Case of Cerebral Sinus Thrombosis with Positive Lupus Anticoagulant Antibody

Abstract

Background: Antiphospholipid syndrome (APS) is characterized by venous and arterial thrombotic events, recurrent fetal loss and the presence of antiphospholipid antibodies. Cases which are not associated with systemic lupus erythematosus or other autoimmune diseases, are called primary APS Early assessment and treatment are very important against vascular complications. Prognosis is usually favourable despite mild or moderate recurrent vascular episodes with minimal disability Objective: A fourtyfour-year-old-woman with primary APS syndrome is presented She admitted to the hospital with left hemiparesis and epileptic seizure, and had no classical vascular risk factors. Magnetic Resonance Venography (MRV), which revealed sinus thrombosis, has been done before and after treatment to evaluate the outcome of the disease. Findings: MRV revealed thrombosis of superior sagittal, right sigmoid, and right transvers sinuses, and positive serum lupus anticoagulant antibodies have been obtained. The patient showed marked improvement both clinically and angiographically at the end anticoagulant therapy for ten days. Conclusion: APS must be considered in young stroke cases without vascular riskfactors. The regression in disability can be obtained by early assessment and treatment, which may result in decreased recurrence risk of vascular complications.