Effect of Duration of Disease on Gait Parameters in Parkinson’s Patients
Aygün Özşahin1, Dilek Günal2, Hülya Demir1, Ayşe Akpınar1, Ali Üçkardeş3, Önder Us2
1Movement Disorders Graduate Program, Department Of Neurology, Marmara University, İstanbul, Turkey
2Department Of Neurology, Marmara University, Faculty Of Medicine, İstanbul, Turkey
3Metin Sabanci Spastic Children Centre, İstanbul, Turkey
Keywords: Parkinson’s disease, gait analysis, kinematics, temporospatial, duration of disease.
Abstract
OBJECTIVE: Posture and gait disturbances are major components which cause functional disability in Parkinson’s disease (PD). Three dimensional gait and motion analysis systems provide quantitative data of gait.
OBJECTIVES: The aim of this study is to correlate between duration of disease and gait parameters of Parkinson patients during the on-phase.
METHODS: We investigated temporospatial and kinematics variables of gait in 23 subjects with PD as measured in the on-phase of their medication cycle using motion analysis. We evaluated the correlation between all gait parameters and Gait and Balance Scale (GABS), unified Parkinson’s disease rating scale (UPDRS) total-motor scores, Hoehn&Yahr (H&Y) stages and duration of the disease.
RESULTS: We found positive correlation between cadance and duration of disease. Patients had negative correlation between stride time and duration of disease. And also there was positive correlation between UPDRS total score and duration of disease.
CONCLUSION: Increasing of cadance and decreasing of stride time exhibited by PD subjects is a compensatory mechanism for the difficulty in regulating stride lenght. It was reported that stride lenght control mediate by basal ganglia. Scaling of lower limb amplitude during locomotion can be controlled by higher levels of the Central Nervous System. Patients tend to increase pelvic rotation to keep their center of mass stabilised because of shortness of stride lenght. We thought that reduction pelvic and hip ROMs in coronal plane are impaired muscles of leg in the swing phase. These findings possibly indicate that shortness of stride lenght with the progression of disease is related to cortical centers. Three dimentional analysis systems provide detailed gait examination in PD patients to assess of progression and efficacy for therapies. Also, this method will guide us to explain physiopathologic mechanisms of PD.