Investigation of Mean Platelet Volume in Patients with Multiple Sclerosis

Ertuğrul Uzar; Adalet Arıkanoğlu; Yavuz Yücel; Birsen Aydın; Mehmet Halis Tanrıverdi; Nebahat Taşdemir

Ertuğrul Uzar¹, Adalet Arıkanoğlu¹, Yavuz Yücel¹, Birsen Aydın¹, Mehmet Halis Tanrıverdi², Nebahat Taşdemir¹

¹Dicle University, Faculty Of Medicine, Department Of Neurology, Diyarbakır, Turkey
²Dicle University, Faculty Of Medicine, Department Of Public Health, Diyarbakır, Turkey

Keywords: Multiple sclerosis, platelet activation, platelets.

Abstract

OBJECTIVE: Alterations in platelet function have been observed in patient with multıple sclerosis (MS). Mean platelet volume (MPV) is a marker of the platelet activity and is reported to increase in vascular diseases. The aim of this retrospective study was to investigate the correlation between MPV and MS.

METHODS: The patient group consisted of 46 MS patients who were presented to MS attacks (males/females: 10/36, mean age: 34.3±9.4). In the MS patients, during the attack MPV value compared with the value of MPV after attack. Also, their MPV values were compared with those of 38 age/sex-matched healthy individuals (males/females: 14/24, mean age: 36.4±10.4).

RESULTS: No difference was found in terms of MPV values between during the attack of MS (8.0±1.2) and after MS attack (7.9±1.2), and no relation was found between MPV and EDSS parameters (p>0.05). No difference was found in terms of MPV values between the MS group (8.1±1.3) and control group (8.1±1.1) (p>0.05).

CONCLUSION: As a result, no significant change in MPV was seen between the during the MS attack and after the MS attack. This finding support that platelet activation not an important role pathogenesis in MS. But, relation between MS and MPV should investigated with prospectively.