The Increase of The Mean Platelet Volume in Patients With Intracerebral Haemorrhage

Adalet Arıkanoğlu; Mehmet Uğur Çevik; Ertuğrul Uzar; Abdullah Acar; Eşref Akıl; Faysal Ekici; Nebahat Taşdemir

doi:10.4274/Tnd.05325

Adalet Arıkanoğlu¹, Mehmet Uğur Çevik¹, Ertuğrul Uzar¹, Abdullah Acar¹, Eşref Akıl¹, Faysal Ekici², Nebahat Taşdemir¹

¹Department Of Neurology, Dicle University Faculty Of Medicine, Diyarbakir, Turkey
²Department Of Radiology, Dicle University Faculty Of Medicine, Diyarbakir, Turkey

Keywords: Intracerebral haemorrhage, mean platelet volume, mortality

Abstract

OBJECTIVE: The mean platelet volume (MPV) is a biomarker of platelet function and activity. The influence of platelet function disorders on the aetiology of intracerebral haemorrhages (ICH) and mortality is not clear yet. The purpose of this study is to investigate the change in the MPV values in patients with ICH and to observe its influence on mortality in a retrospective manner.

METHODS: Sixty-six patients with intracerebral haemorrhage (32 males, 34 females; mean age: 61.9± 16.9) were enrolled in the study. Patients with ICH were divided into two groups as those who died within the first 10 days and those who survived. The MPV values and the haematoma volumes were compared between the groups. Also, the MPV values and platelet counts of the patients with ICH were compared with the values of healthy volunteers from similar age and sex groups (27 males, 17 females; mean age: 59.9 ±3.2).

RESULTS: The MPV values of the patients with ICH measured within 24 hours following the intracerebral haemorrhage (8.33 ± 1.27 fl/mL) were statistically significantly higher than the MPV values of the control group (7.76 ± 1.14 fl/mL) (p=0.018). The platelet counts of the patients with ICH also measured within the first 24 hours (235.8±94.9 x103/mL) were statistically significantly lower than the platelet counts of the control group (279.1 ± 94.9 x103/mL) (p=0.022). No statistically significant difference in terms of the MPV values and platelet counts was observed between the patients with ICH who died within the first 10 days and those who survived (p>0.05). However, the difference observed in the haematoma volume between the patients with ICH who died within the first 10 days (31.1 ±33.7 ml) and those who survived (8.7± 13.4 ml) was statistically significant (p<0.001). No correlation was found between the haematoma volume and the MPV value in the patients with ICH.

CONCLUSION: The increase observed in the mean platelet volume in patients with ICH may point to a disorder in the platelet function. No relationship was found between the increase in the MPV and the mortality rates.