Evaluation of Thiol-disulfide Homeostasis and Ischemia-modified Albumin Levels in Patients Presenting to the Emergency Department in the Postictal Period
İremgül Güngör1
, Ahmet Burak Erdem2, Havva Şahin Kavaklı3, Arzu Kösem4, Özcan Erel4, Salim Nesşelioglu4
1Samsun Training and Research Hospital, Clinic of Emergency Medicine, Samsun, Türkiye
2Ankara City Hospital, Clinic of Emergency Medicine, Ankara, Türkiye
3Yildirim Beyazit University Faculty of Medicine, Department of Emergency Medicine, Ankara, Türkiye
4Yildirim Beyazit University Faculty of Medicine, Department of Biochemistry, Ankara, Türkiye
Keywords: Epilepsy, ischemia-modified albumin, oxidative stress, thiol-disulfide homeostasis
Abstract
Objective: Epileptic seizures are thought to increase oxidative stress. This study aims to show how thiol-disulfide homeostasis (TDH) and ischemia-modified albumin (IMA) values, which are oxidative stress parameters, affect patients with epileptic seizures.
Materials and Methods: This study is a prospective, clinical trial, case-controlled trial. A total of 51 patients who were admitted to the emergency department with epileptic seizures and 51 healthy volunteers were enrolled in this study. Oxidative stress and lactate values were measured from blood samples that were drawn intravenously from the patient group, and these biomarkers were compared with the healthy control group.
Results: Statistically significant differences were found between patients in the epilepsy and control groups for all IMA values (P < 0.001) and for all TDH values except disulfide (P < 0.001). Native thiol and total thiol levels were found statistically significantly lower in patients with status epilepticus than in patients with only epileptic seizures (P < 0.001).
Conclusion: It has been seen that epileptic attack increases oxidative stress. TDH and IMA levels are affected statistically significantly after epileptic seizure. Especially the decrease in native thiol and total thiol levels is noticeable in patients with status epilepticus.
The approval for this study was received from the Ethical Committee of University of Health Sciences Türkiye, Ankara Numune Training and Research Hospital (decision number: 18-2276).
Informed consent forms were provided by all participants.
Externally peer-reviewed.
Concept: İ.G., Design: İ.G., A.B.E., H.Ş.K., Data Collection or Processing: İ.G., A.K., Analysis or Interpretation: A.K., Ö.E., S.N., Literature Search: İ.G., A.B.E., H.Ş.K., Writing: İ.G., A.B.E., H.Ş.K.
No conflict of interest was declared by the authors.
The authors declared that this study received no financial support.