Chronic progressive behavioral changes associated with headache: An atypical presentation of myelin oligodendrocyte glycoprotein (MOG)-associated disease
Neetu Sinha1
, Pawan Prakash2, Abhay Ranjan2
1Department of Radiodiagnosis, Indira Gandhi Institute of Medical Sciences, Patna, India
2Department of Neurology, Indira Gandhi Institute of Medical Sciences, Patna, India
Keywords: Behavioral symptom, myelin oligodendrocyte glycoprotein associated disorder, psychiatric symptom.
Abstract
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease does not have clinical features that are disease-specific, and its clinical spectrum has yet to be defined. Herein, we described an atypical presentation of MOG-related disease. A 26-year-old female presented with behavioral changes in the past seven months in the form of agitation, anger, anxiety, fear of death, panic attacks, and an obsession to repeatedly perform daily activities. The patient also had headache for six months. The patient had a similar history of behavioral abnormality and four episodes of painful visual blurring. Neurological examination was unremarkable except for truncal and gait ataxia. Magnetic resonance imaging of the brain showed hyperintense signals in bilateral subcortical white matter, middle cerebral peduncles, cerebellum, thalamus, and pons with contrast enhancement. Myelin oligodendrocyte glycoprotein antibody was found to be positive by cell-based indirect immunofluorescence assay. The patient was managed with an intravenous methylprednisolone pulse. The patient had complete resolution of symptoms and magnetic resonance imaging brain abnormalities at the one-month control.
Cite this article as: Sinha N, Prakash P, Ranjan A. Chronic progressive behavioral changes associated with headache: An atypical presentation of myelin oligodendrocyte glycoprotein (MOG)-associated disease. Turk J Neurol 2025;31(1):76-79. doi: 10.55697/tnd.2025.149.
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Idea/concept, writing the article: A.R., Literature review: A.R., P.P., N.S.; Data collection: P.P., N.S.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.