Platelet-albumin-bilirubin score and systemic immune-inflammation index for assessing the prognosis of acute ischemic stroke patients

Selcen Duran; Asuman Celikbilek; Aysu Yetis; Burc Esra Sahin; Aydan Koysuren; Memis Bolacalı; Bekircan Polat

doi:10.55697/tnd.2025.232

Selcen Duran¹, Asuman Celikbilek¹, Aysu Yetis¹, Burc Esra Sahin¹, Aydan Koysuren¹, Memis Bolacalı², Bekircan Polat¹

¹Department of Neurology, Kırşehir Ahi Evran University Faculty of Medicine, Kırşehir, Türkiye
²Biostatistics and Medical Informatics, Kırşehir Ahi Evran University Faculty of Medicine, Kırşehir, Türkiye

Keywords: Acute ischemic stroke, platelet-albumin-bilirubin, prognosis, stroke severity, systemic immune-inflammation index.

Abstract

Objectives: This study investigated the prognostic value of the systemic immune-inflammation index (SII) and platelet-albumin-bilirubin (PALBI) score in patients with acute ischemic stroke (AIS).

Patients and methods: A total of 211 patients (120 males, 91 females; mean age: 70.9±13.2 years; range, 25 to 98 years) with AIS and 145 controls (72 males, 73 females; mean age: 69.4±8.4 years; range, 53 to 88 years) were included in this prospective study between March 2023 and December 2023. Demographic data and laboratory results upon admission were recorded. The SII and PALBI scores were calculated from laboratory parameters.

Results: The SII was significantly higher in the stroke group compared to controls (p<0.001), while PALBI scores were similar between the groups (p=0.169). According to the TOAST (Trial of ORG 10172 in Acute Stroke Treatment) classification, SII was comparable across the subgroups (p=0.964), but PALBI scores were significantly higher in the cardioembolic group (p=0.002). In terms of stroke severity, SII showed no significant differences between subgroups (p=0.701); however, patients with moderate-to-severe stroke had significantly higher PALBI scores than those with minor stroke (p=0.008). Both SII (p=0.007) and PALBI scores (p=0.019) were significantly elevated in AIS patients with stroke-related complications.

Conclusion: A higher PALBI score was associated with stroke severity, and both PALBI and SII values were elevated in AIS patients with complications, indicating a poor prognosis.

Cite this article as: Duran S, Celikbilek A, Yetis A, Sahin BE, Koysuren A, Bolacalı M, et al. Platelet-albumin-bilirubin score and systemic immune-inflammation index for assessing the prognosis of acute ischemic stroke patients. Turk J Neurol 2025;31(1):34-40. doi: 10.55697/tnd.2025.232.

Data Sharing Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Author Contributions

Idea/concept: S.D.; Design, control/supervision, analysis and/or interpretation, writing the article, materials: S.D., A.C.; Data collection and/or processing, literature review: S.D., A.Y., B.E.S., A.K., M.B., B.P.; References and fundings: S.D., A.C., A.Y., B.E.S., A.K.; Other: S.D., M.B., B.P.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/ or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.