Evaluation of risk factors and clinical and radiological characteristics in cortical vein thrombosis accompanying cerebral venous sinus thrombosis

Abstract

Objectives: The study aimed to determine the clinical relevance of cortical vein thrombosis (CVT) accompanying cerebral venous sinus thrombosis (CVST) and to investigate the risk factors.

Patients and methods: This retrospective study included 176 patients (52 males, 124 females; mean age: 41.8±14.5 years; range, 16 to 72 years) with CVST between January 2015 and January 2021. The radiological, demographic, and clinical features and risk factors of patients with and without CVT were com-pared.

Results: When the clinical demographic and radiological features associated with CVT were evaluated; there was a significant relationship between age, clinical onset symptom, connective tissue disease, post-partum period, presence of hypercoagulopathy, superior sagittal sinus (SSS) thrombosis, transverse sinus thrombosis, sigmoid sinus thrombosis, non-hemorrhagic venous infarct, small juxtacortical hemorrhage and large parenchymal hematomas, time to diagnosis (days), and poor clinical outcome. When significant risk factors for CVT were analyzed by binary logistic regression, the post-partum period and SSS thrombosis were independent risk factors.

Conclusion: In this study, the rate of CVT accompanying CVST was 30.7%, which is higher than the studies in the literature. Cortical vein thrombosis accompanying CVST is associated with parenchymal lesions and poor clinical outcome; SSS thrombosis and the postpartum period are independent risk factors. Multicenter prospective studies are recommended for more precise information.

Cite this article as: Dinç Y, Ozpar R, Hakyemez B, Bakar M. Evaluation of risk factors and clinical and radiological characteristics in cortical vein thrombosis accompanying cerebral venous sinus thrombosis. Turk J Neurol 2024;30(2):102-107. doi: 10.55697/tnd.2024.133.

The data that support the findings of this study are available from the corresponding author upon reasonable request.

The study protocol was approved by the Bursa Uludağ University Faculty of Medicine Clinical Research Ethics Committee (date: 01.08.2023, no: 2023-15/22). The study was conducted in accordance with the principles of the Declaration of Helsinki.

A written informed consent was obtained from each patient.

Idea/concept, design, references and fundings, materials: Y.D.; Control/ supervision, critical review: M.B., B.H.; Analysis and/or interpretation, literature review: R.Ö.; Writing the article: R.Ö., Y.D.

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

The authors received no financial support for the research and/or authorship of this article.