Emine Kılıçparlar Cengiz1, Yasemin Ekmekyapar Fırat2, Abdurrahman Neyal3, Ayşe Münife Neyal2

1Department of Neurology, Dr. Ersin Arslan Training and Research Hospital, Gaziantep, Türkiye
2Department of Neurology, SANKO University Faculty of Medicine, Gaziantep, Türkiye
3Department of Neurology, Gaziantep Islam Bilim ve Teknoloji University Faculty of Medicine, Gaziantep, Türkiye

Keywords: Apnea hypopnea index, monocyte to HDL ratio, obstructive sleep apnea syndrome, total bilirubin.


Objectives: This study aimed to compare total bilirubin levels with monocyte-to-high-density lipoprotein ratio (MHR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients diagnosed with obstructive sleep apnea syndrome (OSAS) according to the apnea-hypopnea index (AHI) values.

Patients and methods: The files of patients who underwent polysomnography and had total bilirubin and complete blood count values were retrospectively reviewed. Patients were divided into three groups: AHI <5, AHI =5-29.99, and AHI ≥30. All blood parameters and calculated ratios were compared between the groups, and the relationship between these parameters and OSAS severity was investigated.

Results: The study included 240 patients (149 males, 91 females; mean age: 47.4±11.9 years; range, 21 to 82 years). High-density lipoprotein values were significantly lower and MHR was significantly higher in the group with AHI ≥30 compared to the other two groups (p<0.001 and p=0.001, respectively). Apnea-hypopnea index was correlated with MHR (r=0.270, p<0.001). The groups were similar in terms of MLR, NLR, PLR, and total bilirubin levels.

Conclusion: Considering that these easily accessible blood parameters are affected by many factors, they can only be used as auxiliary parameters in assessing the severity and follow-up of diseases such as OSAS.

Cite this article as: Kılıçparlar Cengiz E, Ekmekyapar Fırat Y, Neyal A, Neyal AM. The relationship of complete blood parameters, high-density lipoprotein cholesterol, and bilirubin values with disease severity in obstructive sleep apnea syndrome. Turk J Neurol 2024;30(1):10-15. doi: 10.55697/tnd.2024.84.

Data Sharing Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Ethics Committee Approval

The study protocol was approved by the SANKO University Clinical Research Ethics Committee (date: 27.01.2022, no: 01). The study was conducted in accordance with the principles of the Declaration of Helsinki.

Author Contributions

All authors contributed equally to the article.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.