Evaluating Proteinuria as A Risk Factor For Stroke

Abstract

Determining stroke risk factors constitutes the basis for the strategies for the preventionof strokes. Recent reports have been published showing that proteinuria could alsa a marker of vascular damage . Our purpose in this study was to ascertain whetherproteinuria in stroke patients had any different aspects from that in control group and to determine any possible relationship between proteinuria and other risk factors and its links to clinical manifestations and prognosis . Admitted in our clinic with a diagnose of stroke, 80 patients, who did not have any previous renal, hepatic, hematologic, malign and infectious diseases which were likely to inffuence proteinuria status; and who didnot have previous DM and events for latent diabetes; and who were not given any medication which might give way to proteinuria were taken into the study. In order to determine the level of proteinurea, samples of 24-hour urea were taken in the initial 3 days.No difference could be attained regarding the average age between 80 patients and 33 controls taken into the study. Average level of proteinuria found in 24-hour urea in patients (753,125 ± 168,418) was signifıcantly higher than in controls (78 ,060 ±34,019) (p=0 ,0 12). Levels of serum albumin showed no difference between the two groups while serum globulin appeared to be raised in patients only (p=0,010) . Sistolic blood pressure in patients (159,250 ± 33 ,395) was found higher than in controls(141,212 ± 17,276) (p=0,04) . Diastolic blood pressure in patients (90 ,687 ± 14,181) turned out to be higher than in controls (p=0,001). Proteinuria in patients showed no difference between the male and the female. Levels of proteinuria were higher in patientswith hemorrhagic stroke (1115,625±303,76), than in patients with ischemic stroke(393,589 ± 193,28) (p= 0,033) . As a conclusion, it was thought that proteinurea, especially in hipertensive patients, could be a predictor of stroke and that further studies should be launched for it is an easily attainable and changeable factor.