Cerebrovascular Disease in Childhood: Etiology | 2003, Volume 9 - Issue 1

Ertuğrul ÇETİN¹, İbrahim ÖZTURA², Mustafa BAŞOĞLU³

¹SB Manisa Devlet Hastanesi Nöroloji Kliniği
²Dokuz Eylül Üniversitesi Tıp Fakültesi Nöroloji Ana bilim Dalı
³İzmir Atatürk Eğitim ve Araştırma Hastanesi Nöroloji Kliniği

Keywords: Carbamazepin, Folic acid, Vitamin B12, Somatosensoriel evoked potentials(SEP)

Abstract

Objective: To investigate the relation of long term carbamazepin (CBZ) to the levels of serum vitamin B12 and folic acid and to somatosensoriel evoked potentials (SEP).Material and method: Twenty nine epileptic patients (12 males, 17 females) on CBZ treatment for at least 2 years and aged between 14-55 years were included into the study. Control group consisted of 22 healthy subjects (9 males, 13 females with theaged between 17-48 years. Serum vitamin B 12, folic acid levels were measured and SEP's were recorded from scalp.Results: Patients on CBZ had lower serum vitamin B12 levels than control group (P0.05). Serum vitamin B12 levels and SEP latencies did not show a significant correlation(P>0.05).Conclusion: We found that serum vitamin B12 levels were lower and SEP latencies were longer in epileptic patients on long term caz monotherapy, while folic acid levels were not affected. However serum B12 levels and SEP latency measurements were not correlated.