Raynaud Phenomenon and Elevated Anticardiolipin Antibodies Levels in a Patient With Sneddon's Syndrome

Abstract

Background: Sneddon's syndrome is a rare disease characterized by cerebrovascular ischaemic attacks and generalized livedo reticularis. A wide variety of dermatologic manifestation has been described including livedo reticularis and rarely Reynaoud phenomenon in the Sneddon's syndrome. Case report: We present 42-year-old women with Raynaud phenomenon, livedo reticularis, elevated anticardiolipin antibodies levels and cerebrovasculer lesions with right hemiparesis in whom Sneddon's syndrome was diagnosed. Routine tests including platelets and partial tromboplastine time were normal. Laboratory tests revealed that, ANA, anti ds DNA, monoclonal cryoglobulin, andcryofibrinogen were negative and elevated anticardiolipin antibodies. Magnetic resonance angiography (MRA) was normal. Cerebral MRI images showed bilaterally small deep white matter lesions without contrast enhancement. The skin biopsy was compatible for sneddon syndrome. Conclusion: We present a patients with Raynaud phenomenon, livedo reticularis, ischaemic cerebrovasculer accidents and elevated anticardiolipin antibodies. Arelationship between Sneddon syndrome and antiphospholipid antibodies has been noted as differential diagnosis of Sneddon 's syndrome and antiphospholipid syndrome is important for different therapeutical approaches.