Gökçen Garipoğlu, Bilge Koç, Tuğçe Özlü

Bahcesehir University Faculty of Medicine, Department of Nutrition and Dietetics, Istanbul, Turkey

Keywords: Breath acetone, ketone, ketogenic diet, nanotechnology


Objective: Ketogenic diet may be effective in the treatment of neurological diseases such as epilepsy. Breath acetone measurement can be a practical method in the tracking of ketogenic diet treatment. This study aimed to determine the correlation between breath acetone levels and urinary ketone levels of adult individuals undergoing ketogenic diet therapy.

Materials and Methods: A total of 18 adults, which included 10 adults in the treatment group and 8 adults in the control group, were enrolled in the study. Ketogenic diet therapy was applied to the intervention group for 1 week. For 1 week, breath acetone measurements of both the treatment group and control group were taken every day at the same time on fasting. In all participants, urine ketones were measured at the same time every day.

Results: Breath acetone and urine ketone values on days 3-5 were significantly higher in the treatment group than that in the control group. Positive correlations were found between breath acetone levels and urine ketone levels in the treatment group in all 7 days.

Conclusion: The breath acetone measurement method can be used practically and reliably for ketone monitoring in individuals undergoing ketogenic diet therapy.

Ethics Committee Approval

Approval was obtained from the ethics committee of Bahcesehir University Clinical Research Ethics Committee (decision no: 2019-12/04) was obtained for the study, and procedures were performed according to the ethics standards of the Helsinki Declaration.

Peer Review

Externally peer-reviewed.

Author Contributions

Concept: G.G., Design: G.G., Data Collection or Processing:B.M.K., T.Ö., Analysis or Interpretation: G.G., B.M.K., T.Ö., Literature Search: G.G., B.M.K., T.Ö., Writing: G.G., B.M.K., T.Ö.

Conflict of Interest

G.G. acts as consultant to Avokadio. Avokadio had no role in the design of the study; in the interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Financial Disclosure

The authors declared that this study received no financial support.


We would like to thank Avokadio for their support on the use of sensor.