Reproductive Functions in Male Patients with Epilepsy

Abstract

Objective: Hormonal changes and abnormalities in reproductive function may occur in patients with epilepsy. This study aimed to investigate the abnormalities in the reproductive functions in male patients with epilepsy under antiepileptic treatment and its negative impact on their children.

Materials and Methods: A total of 104 participants were included in the study, wherein 52 were patients and 52 were healthy controls. Medical history and completed neurological examination were performed on all participants. Each participant filled out the International Index of Erectile Function (IIEF) and Beck depression scale. Serum hormones and biochemistry tests were also checked. Electroencephalography that was performed within the last 6 months and cerebral imaging anytime during the follow-up period were retrospectively evaluated. The Statistical Package for the Social Sciences 20.0 program was used for statistical evaluation.

Results: The mean age of the male patients with epilepsy was 29.1±5.5 years. The prevalence of erectile dysfunction was 63.5% in male patients with epilepsy, and 40.4% of the patients developed erectile dysfunction after antiepileptic drug use. Patients on polytherapy were found to have a higher risk of depression. Furthermore, patients with intractable seizures were more depressed (p=0.044). Beck scale and IIEF scores negatively affected each other (rs: -0.568). Patients with polytherapy have higher estrogen levels, whereas the luteinizing hormone levels were lower. Congenital malformation percentage is defined by 4.2% in children of male patients with epilepsy. Two of them have atrial septal defects and 1 with foramen ovale.

Conclusion: The possibility of congenital malformation and abnormalities in the children of male patients with epilepsy should not be overlooked. Patients and their relatives should be provided with the necessary support and information after careful risk assessment.

The Cukurova University Faculty of Medicine Ethics Council approved this study (document dated: 13.01.2017, numbered: 2017/66).

The purpose of the study was explained to the participants before their informed written consent was obtained.

Externally peer-reviewed.

Surgical and Medical Practices: C.Ç., M.T.P., H.B., K.A., Concept: C.Ç., H.B., K.A., Design: C.Ç., M.T.P., H.B., Data Collection or Processing: C.Ç., M.T.P., H.B., K.A., Analysis or Interpretation: C.Ç., M.T.P., H.B., Literature Search: C.Ç., M.T.P., H.B., K.A., Writing: C.Ç., M.T.P., H.B., K.A.

No conflict of interest was declared by the authors.

The authors declared that this study received no financial support.