Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis

Abstract

Objective: We aimed to determine the association between a polymorphism in the promoter region of the IL-1beta gene resulting in enhanced gene transcription and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS).

Materials and Methods: The frequency of a single nucleotide polymorphism (SNP) that results in a C>T transition of 511 base pairs that are five prime to the transcription start site of the IL-1beta gene in a group of 21 patients with TLE+HS, 21 patients with temporal lobe epilepsy without hippocampal sclerosis (TLE-HS), and 23 healthy volunteers.

Results: The frequency of the -511T allele was 11/21 in the TLE-HS group, 13/21 in the TLE+HS group, and 12/23 in the control group. Chi-square analysis of genotype and allele distribution showed no significant difference between the patients in TLE+HS, TLE-HS, and control group

Conclusion: There was no association between the -511/C>T SNP variation and TLE+HS.

The study was approved by the Local Ethics Committee of the University of Health Sciences Turkey, Izmir Tepecik Training and Research Hospital (date: 29/12/2014, no: 21).

All subjects signed the informed consent forms.

Externally and internally peer-reviewed.

Surgical and Medical Practices: A.S., B.Ö., Concept: A.S., İ.F.U., Design: A.S., İ.F.U., Data Collection or Processing: A.S., B.Ö., Analysis or Interpretation: A.S., İ.F.U., B.Ö., Y.Z., U.Ş., F.T., Literature Search: A.S., Writing: A.S., İ.F.U.

No conflict of interest was declared by the authors.

The authors declared that this study received no financial support.