The Factor V Leiden G1691A Mutation in Young Patients Presented with lschemic Cerebrovascular Disease of Posterior Circulation System: 3 Cases

Abstract

Background: Factor V Leiden mutation is one of the important causes of stroke and similar symptoms in young adults. Objectives: Because of Factor V Leiden mutation is a rare condition in clinical practice in young patients who presented with ischemiccerebrovascular disease of posterior circulation system. We were presented three cases to emphasize this pathology in etiology of ischemic disease in young patientsFindings: Factor V Leiden mutation and defect in posterior circulation arterial water shedding was detected in three young patients with who in vestigated for hemiparesis syndrome. Conclusions: Factor V Leiden mutation is the most common known familial thrombotic disorder and usually associated with cerebral venous thrombosis unlike the arterial thrombosis which is reported less frequently. There are rare factor V Leiden mutation cases whose presented with posterior circulation stroke reported in literature. It is important to determine factor V Leid en mutation as a cause of stroke in young patients for cure, prognosis and secondary prophylaxis.