Restless Leg Syndrome and Its Relationship with Parkinson’s Disease

Abstract

OBJECTIVE: Restless legs syndrome (RLS) and Parkinson’s

disease (PD) exhibit striking similarities in impairment of central

dopaminergic transmission and response to dopamine replacement

strategies. The main question is whether RLS and PD are associated

disorders sharing the common pathophsiology and genetic vulnerability

or RLS resulted from nighttime motor disability related to disease itself

or treatment or only a comorbidity. The links and also similarities and

differences between RLS and PD in respect to epidemiology, clinical

features, pathophysiology, neuropharmacology, neurophysiology,

neuroimaging, iron metabolism and genetics were reported below.

METHODS:

RESULTS:

CONCLUSION: