Asymmetrical Lobar Degenerations:  Clinical, Neuropsychological, Scanning Data

Neşe Tuncer, İpek Midi, Tülin Tanrıdağ, Aynur Mollahasanoğlu, Özen Çatan, Önder Us

Department Of Neurology, Marmara University, Faculty Of Medicine, İstanbul, Turkey

Keywords: Asymmetric lobar degeneration, frontal lobe dementia, progressive nonfluent aphasia, corticobasal degeneration syndrome, Pick Complex.

Abstract

OBJECTIVE: Asymmetric lobar degenerations are clinical

syndromes which affect primarily one or more than one cerebral lobe and

result progressive language and/or behaviour and/or cognitive dysfunction.

METHODS:

We report the clinical, neuropsychological and

neuroimaging results of 5 patients with asymmetric lobar degeneration

an one or more than one clinical syndrome according to Frontotemporal

Lobar Degeneration: A Consensus on Clinical Diagnostic Criteria.

RESULTS: Asymmetric lobar degeneration may be one of the largest

entities after Alzheimer Disease to cause dementia. Not only frontal lobe

dementia but also progressive language disorder and corticobasal

degeneration syndrome can be produced by frontotemporal lobar

degeneration and both clinical and pathological overlap of the

syndromes can be seen. The recognition of the relationship between the

clinical syndromes has important implications in the diagnosis and

treatment of dementias.

CONCLUSION: