Neurodegenerative Disorders with Brain Iron Accumulation
Cengiz YALÇINKAYA, Gülçin BENBİR, Güneş KIZILTAN
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Nöroloji Anabilim Dalı, İSTANBUL. [email protected]
Keywords: brain iron accumulation, neurodegenerative disorders, PKAN, basal ganglia, MRI
Abstract
Scientific background: Neurodegenerative disorders with brain iron accumulation include many heterogenous disorders with focal iron accumulation in brain, most prominently in basal ganglia. In addition to hereditary disorders affecting iron metabolism, brain iron accumulation could also be observed during the courses of some other neurodegenerative disorders. Objective: Purpose in this review, iron metabolism and the clinical, radiological, pathological, and genetic features of neurodegenerative disorders with brain iron accumulation are discussed.