Bilateral Basal Ganglia Lesions Associated with Lactic Acidosis in an End-Stage Renal Failure Patient

Babürhan Güldiken; Sedat Üstündağ; Arif Yılmaz; Hasan Çakır

Babürhan Güldiken¹, Sedat Üstündağ², Arif Yılmaz¹, Hasan Çakır²

¹Department Of Neurology, Faculty Of Medicine, University Of Trakya, Edirne, Turkey
²Division Of Nephrology, Department Of Internal Medicine, Faculty Of Medicine, University Of Trakya, Edirne, Turkey

Keywords: Basal ganglia, metformin, lactic, acidosis, kidney failure, chronic, hemodialysis.

Abstract

Although bilateral basal ganglia lesions are common in hypoxic encephalopathy and methanol intoxication, they are a rare finding in end-stage chronic renal failure. The pathophysiology of both bilateral and selective involvement of the basal ganglia is unclear, but severe metabolic acidosis is one of the affected processes. In this report bilateral basal ganglia lesions and accompanying signs, which ensued after the use of metformin in a patient with chronic renal failure, are discussed.