Nistagmus Downbeat Nystagmus Due to Oxcarbazepine Intoxication

Abstract

Downbeat nystagmus is associated primarily with structural lesions of the central nervous system and may be observed as a manifestation of drug intoxication. Herein we present an epileptic patient that presented with downbeat nystagmus related to oxcarbazepine intoxication and completely recovered following dose reduction. To the best of our knowledge this is the first report of downbeat nystagmus related to oxcarbazepine intoxication. Moreover, clinicians should be aware that downbeat nystagmus could be a manifestation of antiepileptic drug intoxication.