Malignant Syndrome in a Patient with Parkinson's Disease

Nesrin Helvacı Yılmaz; Gökçen Duymaz; Mehmet Akif Yaşar

doi:10.4274/Tnd.39358

Nesrin Helvacı Yılmaz¹, Gökçen Duymaz², Mehmet Akif Yaşar²

¹Department Of Neurology, Universal Group Hospital Aksaray, İstanbul, Turkey
²Department Of Anesthesiology And Reanimation

Keywords: Parkinson’s disease, malignant syndrome, levodopa, infection

Abstract

Malignant syndrome during the course of Parkinson’s disease usually occurs because of withdrawal or dose reduction of anti-Parkinsonian drugs, especially levodopa and may be fatal. Fever, rigidity, autonomic disfunction, elevated creatinin kinase level and confusion are the major clinical findings. We aimed to present a patient that was treated in our intensive care unit in order to emphasise the importance of correct diagnosis of this disease, to discuss the precipitating factors and to highlight the importance of early treatment.