Investigation of Total Oxidants/Antioxidants in Patients with Intracerebral Haemorrhage

Mehmet Uğur Çevik; Abdullah Acar; Yavuz Yücel; Sefer Varol; Eşref Akıl; Adalet Arıkanoğlu; Hatice Yüksel

doi:10.4274/Tnd.77698

Mehmet Uğur Çevik¹, Abdullah Acar¹, Yavuz Yücel¹, Sefer Varol¹, Eşref Akıl¹, Adalet Arıkanoğlu¹, Hatice Yüksel²

¹Department Of Neurology, Faculty Of Medicine, University Of Dicle, Diyarbakır, Turkey
²Department Of Biochemistry, Faculty Of Medicine, University Of Dicle, Diyarbakır, Turkey

Keywords: Oxidativestress, intracerebralhemorrhage, Glasgow ComaScale

Abstract

OBJECTIVE: There are numerous study about oxidant and antioxidant status in patients with ischemic stroke however there are few study about this subject in patients with intracerebral hemorrhage (ICH). Malondialdehyde (MDA) is an oxidant parameter which was investigated in patients with ICH, although total oxidant status (TOS) has not been investigated so far. We aimed to investigate in blood samples respectively oxidant and antioxidant parameters MDA and TOS, total antioxidant status (TAS) in patients with ICH.

METHODS: Total of 30 patients with ICH, admitted and treated Neurology Clinic in Dicle University Medical Faculty Hospital and 30 control, had no stroke or any systemic disorder have been included. Peripheral vein blood samples taken from patients and controls were included in the first 24 hours after stroke. Serum TAS, TOS values measured to the original, fully automatic and colorimetric method of Erel. Serum level of MDA was measured according to the method of Ohkawa et al.

RESULTS: According to the control group, the serum levels of TAS, TOS and MDA were significantly higher in patient with ICH (p <0.05). However, there was no correlation between serum TOS, TAS and MDA levels and Glasgow Coma Scale (GCS) total score and hematoma volume (p> 0.05).

CONCLUSION: These findings support that oxidative stress may play a significant role in the pathogenesis of the ICH. However, the increase of these parameters not associated with hematoma volume and GCS in patients with ICH.