Neurological presentation of lymphoma: Report of six cases
Nazire Çelem
, Damla Çetinkaya Tezer, İpek Güngör Doğan, Özdem Ertürk Çetin, Serkan Demir
Department of Neurology, Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, İstanbul, Türkiye
Keywords: Central nervous system, neurologic presentation, primary lymphoma, secondary lymphoma.
Abstract
Primary or secondary lymphomas of the central nervous system may present with various focal or nonfocal neurologic signs and symptoms depending on the location and size of the lesions in the brain and the amount of surrounding edema and mass effect. The most common of these symptoms are cranial nerve deficits, but mental status changes, focal weakness, sensory loss, epileptic seizures, increased intracranial pressure, headache, and radicular pain may also be observed. However, neurological presentations of lymphomas are rare. The diagnosis may be challenging due to the various involvement patterns both clinically and radiologically. Although biopsy is the gold standard method in diagnosis, cerebrospinal fluid cytopathology and flow cytometry are useful in detecting hematological malignancy in the cerebrospinal fluid. Herein, we reported six cases of lymphoma with neurologic presentation.
Cite this article as: Çelem N, Çetinkaya Tezer D, Güngör Doğan İ, Ertürk Çetin Ö, Demir D. Neurological presentation of lymphoma: Report of six cases. Turk J Neurol 2025;31(1):91- 97. doi: 10.55697/tnd.2025.171.
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Idea/concept, design, analysis and/or interpretation, critical review: D.Ç.T., İ.G.D., Ö.E.Ç., S.D.; Control/supervision: Ö.E.Ç., İ.G.D.; Data collection and/or processing; N.Ç., D.Ç.T., İ.G.D.; Literature review, materials: N.Ç., Ö.E.Ç.; Writing the article: N.Ç., Ö.E.Ç., D.Ç.T.; References and fundings; N.Ç.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.