Relationship between subjective sleep quality and serum ghrelin levels in Parkinson’s disease
Alper Ayaslı1
, Yıldız Değirmenci2, Davran Fat3, Mehmet Ali Sungur4
1Department of Neurology, Atatürk State Hospital, Düzce, Türkiye
2Department of Neurology, Medicana Zincirlikuyu Hospital, İstanbul, Türkiye
3Department of Biochemistry, Düzce University Faculty of Medicine, Düzce, Türkiye
4Department of Biostatistics, Düzce University Faculty of Medicine, Düzce, Türkiye
Keywords: Ghrelin, Parkinson’s disease, sleep quality.
Abstract
Objectives: This study aimed to investigate the relationship between serum ghrelin levels and subjective sleep quality in patients with Parkinson's disease (PD).
Patients and methods: This prospective case-control study was conducted between July 2020 and September 2021. Sixty-three patients (39 males, 24 females; mean age: 64.8±12.8; range, 52 to 76 years) diagnosed with idiopathic PD and 59 healthy participants (34 males, 25 females; mean age: 63.9±6.2 years; range, 57 to 59 years) were included in the study. The patients' modified Hoehn and Yahr and Unified Parkinson's Disease Rating Scale scores were determined. Subjective sleep quality of study groups was evaluated with the Pittsburgh Sleep Quality Index, and serum fasting ghrelin levels were measured.
Results: The patient and control groups did not show any significant differences in terms of sociodemographic characteristics. The Pittsburgh Sleep Quality Index values of the patient group were higher compared to the control group (p≤0.001). There was no significant difference between serum ghrelin levels (p=0.329).
Conclusion: A significant relationship was not identified between subjective sleep quality and serum ghrelin levels in PD, and ghrelin did not support the diagnosis of PD. Further studies with larger samples that account for the variability in food intake and the timing of serum ghrelin measurements are needed.
Cite this article as: Ayaslı A, Değirmenci Y, Fat D, Sungur MA. Relationship between subjective sleep quality and serum ghrelin levels in Parkinson’s disease. Turk J Neurol 2025;31(1):69-75. doi: 10.55697/tnd.2025.137.
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Idea/concept, control/ supervision: Y.D.; Design: A.A.; Data collection and/or processing, materials: A.A., F.D.; Analysis and/or interpretation, references and fundings: A.A., M.A.S.; Literature review, writing the article: A.A.; Critical review: A.A., Y.D.
The authors declared no conflicts of interest with respect to the authorship and/ or publication of this article.
The authors received no financial support for the research and/or authorship of this article.