White matter cerebral lesions in patients with migraine and its relationship with the triglyceride-glucose index
Aydın Talip Yıldoğan1
, Ramazan Şencan2, Gözde Öngün3, Bekir Sıtkı Said Ulusoy4, Şeyda Çevik Güneri5, Fettah Eren6
1Department of Neurology, Dr. Ersin Arslan Research and Training Hospital, Gaziantep, Türkiye
2Department of Neurology, 25 Aralık State Hospital, Gaziantep, Türkiye
3Department of Neurology, İstinye University Medical Park Hospital, İstanbul, Türkiye
4Department of Radiology, Gaziantep City Research and Training Hospital, Gaziantep, Türkiye
5Department of Neurology, 25 Aralık State Hospital, Gaziantep, Türkiye
6Department of Neurology, Selçuk University Faculty of Medicine, Konya, Türkiye
Keywords: Migraine, triglyceride-glucose index, white matter lesion.
Abstract
Objectives: The study aimed to investigate the relationship between the triglyceride-glucose (TyG) index and white matter changes in patients with migraine.
Patients and methods: In this prospective case-control study, brain magnetic resonance imaging, fasting triglyceride levels, and fasting glucose levels of 80 patients (69 females, 11 males; mean age: 31.7±9.8 years; range, 19 to 57 years) with migraine and 50 controls (39 females, 11 males; mean age: 29.6±8.6 years; range, 18 to 50 years) were evaluated between January 2023 and January 2024. Headache intensity, frequency, and characteristics were recorded. Headache disability was measured using the MIDAS (Migraine Disability Assessment). White matter hyperintensities (WMHs) were assessed with the Fazekas scale. The TyG index was calculated with the following formula: fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2.
Results: Based on the Fazekas score for white matter hyperintensities (WMHs), the TyG index was significantly higher in patients with Stage 1 and Stage 2 compared to those with Stage 0 (p=0.038).
Conclusion: The findings suggested that an elevated TyG index was associated with the development of WMHs in patients with migraine.
Cite this article as: Yıldoğan AT, Şencan R, Öngün G, Ulusoy BSS, Çevik Güneri Ş, Eren F. White matter cerebral lesions in patients with migraine and its relationship with the triglyceride-glucose index. Turk J Neurol 2025;31(1):46-52. doi: 10.55697/tnd.2025.249.
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Writing, original draft: A.T.Y.; Data collection: Ş.Ç.G, A.T.Y.; Revising the manuscript/study supervision: A.T.Y., R.Ş, G.Ö, Ş.Ç.G, F.E, B.S.S.U.
The authors declared no conflicts of interest with respect to the authorship and/ or publication of this article.
The authors received no financial support for the research and/or authorship of this article.