Relationship between trigeminal neuralgia and the C-reactive protein/albumin ratio
Fatma Ebru Algul
, Fatma Beyza Unver
Department of Neurology, İnönü University Faculty of Medicine, Malatya, Türkiye
Keywords: C-reactive protein/albumin ratio, inflammation, trigeminal neuralgia.
Abstract
Objectives: This study aimed to assess whether the C-reactive protein/albumin ratio (CAR) is a risk factor for trigeminal neuralgia (TN) development and the relationship between the CAR and TN pain frequency.
Patients and methods: In this retrospective study, 100 patients (51 females, 49 males; mean age: 58.6±14.1 years; range, 31 to 88 years) with idiopathic TN and 70 healthy controls (38 females, 32 males; mean age: 54.1±15.7 years; range, 21 to 89 years) were included between January 2020 and December 2022. Patients were divided into two groups by weekly and monthly pain frequency. The laboratory findings and CARs were compared.
Results: The CAR values were significantly different between the patient and control groups (p<0.05) and were significantly different among TN subgroups divided according to attack frequency (p<0.05).
Conclusion: Since there was a significant relationship between TN and CAR as a prognostic predictor, this relationship demonstrated once again that inflammation plays a role in the etiopathogenesis of TN. As opposed to previous studies that investigated the effect of only inflammation, the effects of both inflammation and malnutrition could be investigated by evaluating CAR in this study.
Cite this article as: Algul FE, Unver FB. Relationship between trigeminal neuralgia and the C-reactive protein/albumin ratio. Turk J Neurol 2024;30(3):134-140. doi: 10.55697/ tnd.2024.134.
The data that support the findings of this study are available from the corresponding author upon reasonable request.
The study protocol was approved by the İnönü University Faculty of Medicine Ethics Committee (date: 24.01.2023, no: 2023/4389). The study was conducted in accordance with the principles of the Declaration of Helsinki.
A written informed consent was obtained from each patient.
Conceptualization, resources: F.E.A., F.B.U.; Data curation: F.B.U.; Methodology, project administration, supervision, writing-original draft, writingreview & editing: F.E.A. All the authors contributed to the study conception and design.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.