Emiş Cansu Yaka1,2,3, Şermin Genç2,3,4

1Department of Neurology, İzmir City Hospital, İzmir, Türkiye
2Department of Neurosciences, Dokuz Eylül University, Institute of Health Sciences, İzmir, Türkiye
3İzmir Biomedicine and Genome Center, İzmir, Türkiye
4Dokuz Eylül University, İzmir International Biomedicine and Genome Institute, İzmir, Türkiye

Keywords: Alzheimer’s disease, proximity extension assay, proteomic.


Alzheimer's disease (AD) is the most common neurodegenerative disease in older age. Pathophysiological changes begin in the brains of affected individuals many years before any clinical signs are observed. Although brain imaging and neurophysiological analyzes are useful to reveal anatomical and functional changes in patients whose diagnosis of AD is considered based on clinical examination, their contribution to the diagnosis is quite limited, particularly in the early stages of the disease. Some biological markers are important as laboratory support in the early diagnosis of AD. Biomarkers are objectively measurable and evaluable indicators that serve to identify normal biological processes, pathological processes, and therapeutic response rates. Biomarkers have the potential to predict the likelihood of disease, assist in early diagnosis, and contribute to monitoring treatment effectiveness. This article aimed to provide information about the use of proximity extension assay technology in biomarker studies in AD.

Cite this article as: Yaka EC, Genç Ş. Proximity extension assay-based proteomic studies in Alzheimer’s disease. Turk J Neurol 2024;30(2):69-75. doi: 10.55697/tnd.2024.96.

Data Sharing Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Author Contributions

Wrote the first draft of the manuscript: E.C.Y.; Revised: Ş.G.; Contributed to the manuscript and approved the submitted version: E.C.Y., Ş.G.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.