Piribedil-induced Reversible Pisa Syndrome in a Patient with Lewy Body Dementia
Murat Mert Atmaca
, Başar Bilgiç, Haşmet Hanağası
Istanbul University, Istanbul Faculty of Medicine Hospital, Clinic of Neurology, Istanbul, Turkey
Keywords: Parkinsonism, Pisa syndrome, piribedil, dopamine agonists
Abstract
Pisa syndrome (PS) has been described for the first time as a side effect of neuroleptic treatment in patients with schizophrenia. After its first description, PS was reported in patients on dopamine receptor antagonists, cholinesterase inhibitors, and antidepressants. PS was also associated with neurodegenerative diseases such as Alzheimer’s disease, multiple system atrophy, and dementia of Lewy bodies (DLB). Dopaminergic treatment in Parkinson’s disease (PD) may also lead to PS in PD patients. Here, we report a patient with probable DLB who developed PS after the initiation of piribedil treatment. After cessation of piribedil, PS disappeared entirely. We want to highlight that PS related to dopaminergic treatment may be reversible, and like other dopamine agonists, piribedil has the potential to cause PS in patients with parkinsonism.
Informed consent was obtained from the patient.
Internally peer-reviewed.
Surgical and Medical Practices: B.B., H.H., Concept: B.B., H.H., Design: M.M.A., Data Collection or Processing: M.M.A., Analysis or Interpretation: B.B., H.H., Literature Search: M.M.A., Writing: M.M.A.
No conflict of interest was declared by the authors.
The authors declared that this study received no financial support