The Evaluation of the Effect of Flumazenil in Hepatic Encephalopathy by Median Nerve Somatosensory Evoked Potentials
Musa ONAR1, Ziya ARIK1, G. KESİM2, Hakkı KAHRAMAN2, Esin ÖZYILKAN2
1Ondokuz Mayıs Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, Samsun
2Ondokuz Mayıs Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Samsun
Keywords: Flumazenil, hepatic encephalopathy, somatosensory evoked potentials
Abstract
In order to evaluate the effect of flumazenil, a benzodiazepine receptor antagonist, onhepatic encephalopaty, 10 patients with hepatic encephalopaty with abnormal SEPs werestudied after 1,2,6 mg Flumazenil were given intravenously. Median nerve SEPs wererecorded. There were no significant differences between the values of N20 wave latency, N20-P23 wave amplitude and central conduction time (N13- N20 wave peak interval)according to the Wilcoxon paired test(P>0.05).