Brainstem Auditory Evoked Potentials on the Patients Taking Carbamazepin, Phenytoin and Valproic Acid

Abstract

In using antiepileptic drugs for long periods, central nervous system can be effectedthe functions without indicating any clinical neurotoxiticite. The results of the studies on the effects of cronic usage of antiepileptic drugs on brainstem auditory evoked potentials have been different from each other. This study was carried out on, 24, 12 and 12 subject, in total of 48, who had been using respectively carbamazepin, phenytoin and valproic acid for at least 6 months at the of experiment. A control group of 20 subjects in healthy conditions were volunteers in this experiment. During the studies, significant response time delay was detected which were taken from right ear of those subjects using carbamazepin, phenytoin and valproic acid in brainstem auditory evoked potentialsof III-V interpeak latance in comparison to control group. Whereas almost no elongate was detected in either of other test groups.