Haşmet A. HANAĞASI1, Gülüstü KAPTANOĞLU2, Murat EMRE1

1İstanbul Tıp Fakültesi Nöroloji Anabilim Dalı Davranış Nörolojisi ve Hareket Bozuklukları Birimi
2Cognitive Neurology and Alzheimer's Disease Resarch Center Northwestern University, Chicago

Keywords: Parkinson's disease, motor fluctuations, apomorphine

Abstract

Apomorphine, a D 1 and D2 receptor agonist was the first dopaminergic drug everused to treat symptoms of Parkinson's disease (PD). In the last decade subcutaneous infusions of apomorphine have been shown to improve motor complications of late stage PD. in this article treatment with the apomorphine in PD and its role as a diagnostic tool far assessing dopaminergic responsiveness are reviewed.