The Use of Apomorphine in Parkinson 's Disease | 2001, Volume 7 - Issue 2

Haşmet A. HANAĞASI¹, Gülüstü KAPTANOĞLU², Murat EMRE¹

¹İstanbul Tıp Fakültesi Nöroloji Anabilim Dalı Davranış Nörolojisi ve Hareket Bozuklukları Birimi
²Cognitive Neurology and Alzheimer's Disease Resarch Center Northwestern University, Chicago

Keywords: Parkinson's disease, motor fluctuations, apomorphine

Abstract

Apomophine, a D1 and D2 receptor agonist, was the fırst dopaminergic drug ever usedto treat symptoms of Parkinson's disease (PD). In the last decade, subcutaneous infusions of apomorphine have been shown to improve motor complications of late stage PD. in this article treatment with the apomorphine in PD and its role as a diagnostic tool for assessing dopaminergic responsiveness are reviewed.