Motor nöron hastalýðýnda olgularýn %5-lO'u ailevi özellik göstermektedir. Otozomal dominant geçiþli olduðu bilinen bu durumda ailelerin de yaklaþýk % 20'sinde Süperoksit Dismutaz (SOD) geninde mutasyon saptanmaktadýr SOD geninde farklý mutasyonlarýn gösterildiði aileler mevcuttur. Bu çalýþmada Türkiye'den bir motor nöron hastalýðý ailesi (A-MNH) sunulmaktadýr. Üç kuþaktan toplam beþ üyesinde hastalýk saptanan bu ailede hastalýk baþlangýç yaþý 25 ile 48 arasýnda deðiþmektedir. Olgularýn hastalýklarýnýn seyir hýzý birbirinden çok farklýdýr; üç yýl içinde kaybedilen iki olgunun yaný sýra 10 yýlý aþkýn süredir yaþamý fazla kýsýtlanmadan yaþayan olgular da vardýr Ýki olguda hastalýðýn doðum sonrasýnda ortaya çýkmýþ olmasý dikkat çekicidir. Yapýlan genetik inceleme sonucunda hasta bireylerde CuZnSOD geninde G37R olarak adlandýrýlan tipte mutasyon saptanmýþtýr. Bilgilerimize göre Türkiye'den ilk kez bir A-MNH ailesinin genetik incelemesi bildirilmektedir Baþlangýç süresi ve seyir açýsýndan çok büyük farklýlýklar gösteren bireylerin bulunmasý, bu genin olumlu veya olumsuz prognostik deðer taþýmadýðýný düþündürmektedir.

Nearly 5 to 10 % of the cases with motor neuron disease show familial recurrence with anautosomal dominant inheritance. In about 20% of these familial cases, a mutation can be detected in the superoxide dismutase (SOD) gene. Many different mutations have been shown in the SOD gene. In this study a familial motor neuron diseasefamily (F-MND) is presented. In this family with five affected members from three generations, age at onset of disease varies between 25 and 48. Disease courses of the cases are also highly variable; two cases are lost after a rapid course of three years, while there are cases living without much disability for more than 10 years. In two cases disease onset coincided with a recent birth. Genetic analysis revealed G37R-type mutation in theCuZnSOD gene. To our knowledge, this is the first genetic analysis of a F-MND family reported from Turkey. Presence of cases with highly variable age at onset, and clinical course within the same family, suggests that this gene does not carry a positive or negative prognostic value.

Bu çalýþmada klinik bulgulara ilave olarak CT ve MR gibi görüntüleme yöntemleri ile intra -kranial yer kaplayan kitle, histopatolojik olarak da glial tümör tanýsý almýþ olan 35 olguda biyopsi materyalinden tümör kültürü hazýrlanarak karyotip analizi yapýldý. 27 olguda tümör kültüründe üreme elde edilebildi. 6 olguda üreme olmadý. 2 olguda analiz yapmaya elveriþli metafiz plaðý elde edilemedi. 21 olguda 17p delesyonu saptandý. 2 olguda 17p delesyonuna ek olarak 22. kromozomda, 2 olguda 9. ve bir olguda da 10. kromozomda monosomi bulundu. 6 olguda floresan insitu hibridizasyon (FISH) tekniði ile p53 gen mutasyonu incelemesi yapýldý ve dört olguda bu mutasyon saptandý.

In this study, 35 glial tumors diagnosed by CT, MR and histopathologically, were investigated for chromosomal aberration by caryotip analysis on tumor culture. In addition, p53 gene mutation was investigated by FISH techniqe on 6 glial tumors. l7p deletion was found on 21 cases. Besides monosomi was shown on chromosome 22, 10 and 9.P53 gene mutation was found by FISH tecnique on 4 of 6 glial tumor.

Çalýþmanýn amacý kortikal ve subkortikal demanslarda kognitif fonksiyonlarý deðerlendirmek elektroensefalografi (EEG) ve geç latans potansiyel (P300) bulgularý arasýndaki iliþkileri ortaya koymaktýr Deðiþik mental testler 20 Alzheimer hastalýðý (AH), 30 Parkinson hastalýðý (PH) ve 20 kiþilik kontrol grubuna uygulanmýþ, demanslarda elekrofizyolojik ve nöropsikolojik ölçümler arasýndaki iliþki incelenmiþtir AH'da EEG deðiþiklikleri 9 (%45) hastada diffüz veya bitemporal zemin aktivitesinde yavaþlama, delta ve teta frekansýnda artma, hýzlý aktivitede azalma þeklinde bulundu. P300 latansýnda uzama 16 (%80) hastada, amplitüd depresyonu 15 (%75) hastada bulundu, bu elektrofizyolojikdeðiþiklikler aym yaþ grubundaki kiþilerle karþýlaþtýrýldýðýnda önemli idi (p<0 .001). Elektrofizyolojik anormalliklerin hepsi de önemli derecede hafýza, oryantasyon, isimlendirme, yazma ve hesaplama bozukluklarý olan hastalardý. PH'da hafif EEG deðiþikliði kaydedildi (% 1 O hastada). PH'da P3 deðerleri demans bulgularýyla paralellik gösterdi.Demans olmayan PH'da normal elektrofizyolojik bulgular elde edildi. EEG'nin kognitif deðiþikliklerin derecesi ve tipini göstermede hassas olmadýðý, P3 bulgularýnýn demanslarda klinikle korele olduðu ve tanýya önemli katkýlarý olabileceði düþünüldü.

The aim of this study is to evaluate cognitive functions in dementia and to evaluate electroencephalography (EEG) and event related potentials (ERP-P 300) findings, to correlate any relationship between cognitive functions and neurophysiological values in demented patients. The various cognitive and mental state tests were assessed in 30 patients with Parkinson's disease and 20 patients with dementia of the Alzheimer's type, 20 control group. Interaction between electrophysiological and neuropsychological measures have been studied in patients with dementia. EEG changes were detected in 9 (45%) patients with AD in the form of deceleration in diffuse or bitemporal backgroundactivity, increase in delta and theta frequency, decrease in rapid activity . Prolongation in P300 latency was observed in 16 (80%) patients, amplitute depression in 15(75%) patients. These electrophysiological changes were found to be significant when compared with control in the same age (p<0.001). All of the electrophysiological abnormalities werein the patients with a important degree of impairment of memory, orientation, naming, writing and calculation functions. Mild EEG changes was observed in PD and normal electrophsiological findings were found in nondemen ted PD. P3 values were according to dementia symptoms. It is concluded that EEG was not an occurate means of demonstrating the degree and type of cognitive change; that auditory event related potential was correlated with impairment of cognitive functions and finally that they could contribute to the diagnosis of dementia.

Parkinson hastalýðýnda (PH) somatosensoryel uyarýlmýþ potansiyellerin (SUP) N30 potansiyelinin etkilendiði yolundaki literatür bilgileri çeliþkilidir. Bu çalýþmada PH'da SUP'lerin frontal, santral ve parietal komponentlerinde etkilenme olup olmadýðýný belirlemek amacý ile hemiparkinson (HP) tanýsý ile izlenen 19 hasta (15E,4K) ve 9 (3E,6K)normal gönüllü denekde orta latanslý somatosensoryel uyarýlmýþ potansiyel (OLSUP) çalýþmasý yapýldý. Frontalden kaydedilen P14, P20, N30 latans ve P20/N30 amplitüd, santralden kaydedilen N18, P22, N32, P40 latans ve N18/ P22, N32/P40 amplitüd, parietalden kaydedilen N20, P27, N34, P40 latans ve N20/P27, N34/P40 amplitüdlerideðerlendirildi. HP'lu hastalarýn hasta ve saðlam taraflarý arasýnda anlamlý latans veya amplitüd deðiþikliði saptanmadý. Normal gruba göre HP'lu hastalarýn frontalden kaydedilen N18/P22 amplitüdü düþük, P14 latansý uzun ve parietalden kaydedilen P40 latansý uzun bulundu. Unified Parkinson's Disease Rating Scale (UPDRS) motor skoru ile N18/P22, N20/ P27 ve N32/P40 amplitüdleri arasýnda pozitif, hastalýk süresi ile N18/P22 ve N20/P27 amplitüdleri arasýnda negatif korelasyon saptandý. Sonuçlarýmýz, PH'da ortabeyin ile motor ve premotor korteks arasýndaki yollarda etkilenme olduðunu düþündürmüþtür.

The reports in the literature regarding the effect of Parkinson's disease (PD) on the frontal N30 components of the somatosensory evoked potentials (SEPs) are contraversial. In order to assess whether frontal, central and parietal components of SEPs are influenced in PD, we studied middle latency SEPs in 19 patients (15 males, 4 females) with hemiparkinsonism (HP) and in 9 (3 males, 6 females) healthy controls. Frontal P14, P20, N30 latencies and P20/N30 amplitudes; central N18, P22, N32, P40 latencies and N18/P22, N32/P40 amplitüdes; parietal N20, P27, N34, P40 latencies and N20/P27, N34/P40 amplitudes were evaluated. There was no significant difference in latencies and amplitudes between the affected and unaffected sides of patients. Compared with the controls, HP patients exhibited lower frontal N18/P22 amplitudes, longer parietal P14 latencies and longer parietal P40 latencies. There was a positive correlation between the Unified Parkinson's Disease Rating Scale (UPDRS) motor score and N18/P22, N20/P27 and N32/P40 amplitudes; while a negative correlation was found between the duration of the disease and N18/P22 as well as N20/P27 amplitudes. Our results suggest that the pathways between the midbrain and both the motor and premotor cortex are affected in PD.

Bu çalýþmanýn amacý Isparta ilinde inme insidansý ve inmeye baðlý akut dönem ölüm oranlarýnýn saptanmasýdýr 1 Ocak 1993-31 Aralýk 1997 arasýndaki beþ yýllýk sürede Isparta ilinin 18 yaþ üzerindeki ortlaama nüfusu 263.797 idi. Bu süre içinde, 18 yaþýn üzerinde 1747 vaka vardý. Bu populasyonda inme insidansý 1.51/ 100.000 olarak saptandý. 75 yaþ yukarýsý haricinde insidans yaþla artmaktaydý. Cinsler arasý insidans daðýlýmýnda istatistiksel olarak anlamlý bir fark yoktu. Serebral infarkt %65,7 oranýyla en çok görülen inme tipiydi. Ýnsidans tüm inme tiplerinde yaþla birlikte artmaktaydý.ilk bir aylýk akut fazda ölüm oraný tüm vakalarda %13.1, serebral infarklarda % 10.3, intraserebral kanamalarda %21.1 ve subaraknoid kanamalarda da %21,l idi. Sonuçlarýmýzýn çoðu literatür ile büyük oranda uyumlu idi. Fakat Isparta ilinde 75 yaþ üzerindeki inme insidansý geliþmiþ ülkelere göre daha düþüktür.

The purpose of this study is to determine the rates of stroke incidence and case fatality during acute phase of stroke in Isparta province. In this city between January 1, 1993 and December 31, 1997 The average of population above 18 years of age was 163, 797. During this five years period, 1717 cases among this population was assessed. The rate of stroke incidence was 151 Per 100.000 inhibants> 18 years. It was seen that the incidence of stroke increased steply with age up to 75 years of age. There wasn't any statically difference of incidence between sexes. The commonest type of stroke wascerebral infarction by 65. 7%. During the acute phase the rate of case for all stroke cases was 13.1 %, for cerebral infarction 10.3%, for intracerebral hemorrhage 21.1 %, and that for subarachnoidal hemorrhage 21.1%.In conclusion, The most of our results were shown to be similar to those reported from most of other studies, but the incidence rates of stroke above 75 years of age in Isparta province were lower than in the developed countries.

Hiperhomosisteineminin prematüre arteroskleroz ve vasküler okluzif hastalýklar için bir risk faktörü olduðu bilinmektedir Çalýþmamýzda, iskemik strok geçiren 155 hasta ve 40 kiþilik kontrol grubunda homosistein düzeylerine bakarak hiperhomosisteineminin iskemik strok için bir risk faktörü olup olmadýðýný araþtýrdýk. Hasta grubunda ortalama homosistein düzeyi 21.84±8.5 µmol/l, kontrol grubunda 1032 ± 4.28 µmol/l olup iki grup karþýlaþtýrýldýðýnda hasta grubundaki yükseklik istatistiksel olarak anlamlý bulundu (P<0.001). Ayrýca 9 hastada homosistein yüksekliði dýþýnda baþka bir risk faktörü tespit edilmedi. Sonuçlarýmýz, hafif veya orta derecedeki hiperhomosisteineminin strok için bir risk oluþturabileceðini düþündürmektedir

It was shown that hyperhomocysteinemia is a risk factor premature atherosclerosis and vascular occlusive disease. To determine whether byperbomocysteiýýemia is a risk factor for ischemic stroke, plasma homocystein levels were measured in 155 stroke patients and 40 control subjects. The mean plasma homocystein level was 21.84±8.5 µmol/l in stroke patients and 1032 ± 4.28 µmol/l in control group. Difference between two groups was significant (p<0.001). Additionally, we couldn't detect any risk factor except hyperhomocysteinemia in 9 patients with stroke. Results of this study indicate thatmild or moderate hyperhomocysteinemia might be a risk factor for stroke.

Bu çalýþmada Spontan Subaraknoid Kanaýna (SAK)'larda preoperatif nimodipin kullanýmýnýnprognoza etkisi araþtýrýldý. Toplam 102 hastadan 51'i (ortalama yaþ 53.6) preoperatif dönemde sadece anti-ödem tedavi alýrken;51'ine (ortalama yaþ 50.9) anti-ödem tedaviye ilaveten 360 mg/gün dozunda,ortalama 16.3(2-28) gün süre ile nimodipin verildi. Nimodipin alan gruptaki 44 hastaya serebral anjiografi yapýldý;24 hastada intrakraniyal anevrizma saptandý. Bu gruptaki 27 hasta defisitsiz externe edilirken; 12 hastada nörolojik defisit geliþti, 12'si de exitus oldu. Kontrol grubunda ise 43 hastaya serebral anjiografi yapýldý; 32 hastada intrakraniyal anevrizma saptandý.25 hasta nörolojik defisitsiz externe edilirken, 13 hasta da exitus oldu. Her iki grubun sonuçlarý "ki kare" ve "wilcoxon" testleri ile karþýlaþtýrýldý; istatistiksel olarak anlamlý fark saptanmadý. SAK'larda preoperatif dönemde nimodipinin tedaviye ilavesi prognoza etkisiz bulundu.

The effect of nimodipine preoperatively use on spontan subarachnoid hemorrage is investigated. Total 102 patients, 51 of them treated with anti-edema preoperatively (mean age 53.6) and the other 51 nimodipine 360 mg/day (mean day 16.3) added to anti-edema treatment (mean age 50.9). Cerebral angiography performed on 44 patients in nimodipine group and 24 intracranial aneursym determined. In this group, 27 patients had 110 neurological deficit, 12 patients had permenants neurological deficit and there were 12 exitus. In control group, cerebral angiograpby performed on 43 patients and 32 intracranial aneursym deter-mined. In this group 25 patients had no neurological deficit, 13 patients neurological deficit and there were 13 exitus. Results of these two groups compared "X quare" and "wilcoxon" tests. These two groups are stastically insignificant.Adding nimodipine to preoperatively treatment of subarachnoid hemorrage had no effect on prognosis.

Ventriküler malign aritmi kökenli kardiyak arrest, serebrovasküler olaylarda akut dönemdeki ölüm nedenleri arasýnda en önemli sebeplerden birisidir. Deneysel ve klinik çalýþmalarda uzamýþ ventriküler de-repolarizasyon intervallerinin malign ventriküler aritmilere sebep olduðu gösterilmiþtir. Bu çalýþmada 11 intraserebral hemoraji ve 32 serebral infarkt olgusunda 1. gün ve 7. günde 50 mm/s hýzýnda, 2 m V amplitüdünde EKG kayýtlarý yapýldý. Her EKG'de QT, QTc, JT, JTc intervalleri ölçüldü ve bunlara ait dispersiyon deðerleri (QT-d, QTc-d, JT-d, JTc-d) hesaplandý. Intraserebral hemoraji olgularýnda de-repolarizasyon parametrelerinde istatistiksel farklýlýk gözlenmezken, infarkt olgularýnda 7. gün interval deðerlerinde 1. gün interval deðerlerine göre anlamlý bir artýþ saptandý (p<0.05). Dispersiyon deðerleri ise benzerdi. Gruplar kendi aralarýnda karþýlaþtýrýldýðýnda, yalnýzca infarkt olgularýna ait 7. gün interval deðerleri hemoraji olgularýnýn 7. gün interval deðerlerinden anlamlý olarak daha yüksek bulundu (p<0.05). Sonuç olarak akut dönemde özellikle infarkt olgularýnda hemoraji olgularýna göre ventriküler aritmi kökenli kardiyak arrest riski daha yüksek olarak görülmektedir. Serebrojenik kardiyak aritmiler açýsýndaninfarkt olgularýnýn daha dikkatli takip edilmesi gerektiði kanýsýna varýlmýþtýr.

Cardiac arrest due to ventricular malign arrythmia is one of the most important causes of mortality during acute stroke. In most clinical and experimental studies; it is reported that prolonged ventricular de-repolarisation intervals may predispose to malign ventricular arrythmia. In this study, eleven intracerebral hemorrhage (IH) and thirtytwo cerebral infarction (CI) patients were recorded with a paper speed of 50 mm per second and standardisationof 2 mV a standard 12 leads ECG on first and seventh days of stroke attack. The durations of ventricular repolarisation parameters (QT, JT, QTc and JTc) and repolarisation dispersion parameters (QTd, JTd, QTc-d and JTc-d) were calculated in the standard leads. There was no statistical signficance in ventricular de-repolarisation parameters of IH patients. However; in CI patients; there was significant increase on seventh day values of QT, JT, QTc and JTc intervals according to first day values (p<0.05). Dispersion values were statistically nonsignificant between two groups. When subgroups of stroke analysed, patients in CI had a significantly longer values of QT, JT, QTc and JTc intervals on seventh day than those of IH (p<0.05). The result of this study suggest that CI patients should be more carefully evaluated for cerebrogenic cardiac arrythmia.

Myastenia gravisin (MG) genç ve yaþlýlarda baþlayan olmak üzere 2 tipi olduðu ilerisürülmüþtür. Bu çalýþma MG'in genç ve yaþlýlarda görülen formlarýnýn klinik özelliklerininsaptanmasý amaçlanmýþtýr. Ankara Üniversitesi Týp Fakültesi Nöroloji ABD'da 1988-1998 yýllarý arasýnda yatýrýlarak izlenen 63 hastanýn dosyasý retrospektif olarak incelenmiþtir. Elli üç hasta 10-49 yaþlar arasýndadýr (grup 1), 10 hasta ise 49 yaþýn üzerindedir (grup 2). Hastalýðýn ilk pikini 20'li yaþlarda, ikinci pikini ise 40 'lý yaþlarda yaptýðý görülmüþtür. Kadýnlarda MG en sýk 20-29 yaþlarý arasýnda görülürken erkeklerde 40-49 yaþlarýnda görülmektedir. Genç ve yaþlý grup arasýnda prognoz açýsýndan fark saptanmamýþtýr. Timus BT'si normal olup timektomi yapýlan hastalarýn timus patolojisinde % 64.7'sinde hiperplazi, ektopik timus ya da bunlarýn her ikisi saptanmýþtýr. Maksimal timektomi yapýlan hastalarda prognozun submaksimal timektomiye göre daha iyi olduðu görülmüþtür.

It has been suggested that myasthenia gravis (MG) has two types as early and late onset. It was aimed to determine clinical characteristics of early and late onset MG in this study. It was reviewed files of 63 patients with MG who had been hospitalized to Department of Neurology, Ankara University Faculty of Medicine between 1988-1998. Fifty-three patients were 10-49 years old (group 1), 10 patients were older than 49 years old (group 2). it was seen that disease's first peak was at 20th years and second peak was 40th years old. The peak age of onset between 20-29 years in women and 40-49 years in men. There was no prognosis difference between group 1 and 2. Sixty-five percent of the patients who performed thymectomy showed hyperplasia, ectopic thymus or both although their thymus CT were normal. Prognosis was better patients who performed maximal thymectomy than submaximal thymectomy.

Radial sinir incelemelerinde iðne elektrodlarýn kullanýlmasý nedeniyle birçok EMG laboratuvarýnda radial motor ve duyu sinir iletim çalýþmlarý ender olarak uygulanmaktadýr. Yüzeyel kayýt elektrodlarý kullanarak laboratuvarýmýza ait normal deðerleri belirlemeyi ve daha kolay, rahat uygulanabilir test haline getirmeyi amaçladýk. Kýrk dokuz saðlýklý konrolde önkol-dirsek, 25'inde dirsek-spiral oluk, 23'ünde dirsek-aksilla segmentlerinde motor iletim incelendi. Radial sinir önkol segmenti duyu iletimi 26 saðlýklý bireyde ortodromik yöntemle test edildi. Bulgular önceki çalýþmalarýn sonuçlarý ile kýyaslandý.

Radial motor and sensory nerve conduction studies are infrequently performed in most EMG laboratories. This is largely due to the routine use of needle electrodes in the study of this nerve. We used superficial recording electrodes and determined the normal radial nerve conduction values in order to make this test easier and more applicable. We performed forearm-elbow radial motor conductions in 49 healthy controls; elbow-spiral groove conductions in 25 and elbow-axilla conductions in 23. Radial nerve forearm sensory conduction was done in 26 normal controls using the orthodromic method. Results were compared with those of the previous studies.

Bu çalýþmada diðer kliniklerde yatan hastalardan; nöroloji konsültasyonu istenme nedenlerinin, sýklýðýnýn ve ilk kez bizim tarafýmýzdan oluþturulmuþ olan kriterlerle istenen bu konsültasyonlarýn verimlilik indekslerinin saptanmasý amaçlanmýþtýr. Her bir hasta için; sosyodemografik bilgileri, konsültasyon istek nedenini, yatýran kliniðin tanýsýný,hastanýn yatýþ tarihini, konsültasyon isteme tarihini, konsültasyonun yapýldýðý tarihi, nörolojik taný veya öntaný ve izlem sonuçlarý ile ilgili bilgileri içeren formlar oluþturulmuþtur. Ocak-Haziran 1998 tarihleri arasýndaki 6 aylýk süreçte yatýþý yapýlmýþ olan 1560 hastadan 172'sine nöroloji konsültasyonu istenmiþ ve bu olgular bir nöroloji uzmaný tarafýndan deðerlendirilmiþtir. Yatan hastalardan nöroloji konsültasyonu isteme sýklýðý %11 olarak bulunmuþtur. En çok iç hastalýklarý, enfeksiyon hastalýklarý ve kulak burun boðaz kliniklerinden konsültasyon istendiði ve konsültasyon isteme gerekçesi olarak da en sýk paroksismal bozukluklar (baþ aðrýsý, vertigo) bildirildiði gözlenmiþtir. Dahili dallarýn istemiþ olduðu konsültasyonlarda verimlilik indeksi cerrahi dallarýndan daha yüksektir. KBB, Ortopedi ve Göz anabilim dallarý dýþýndaki cerrahi dallarýn konsültasyon isteme oranlarý ve konsültasyon verimlilik indeksleri çok düþük bulunmuþtur Cerrahi dallarda radikal yöntemlerin yoðun kullanýlmasý ve hospitalizasyonun dahili dallara göre daha kýsa süreli olmasýnýn bunda etken olduðu düþünülmüþtür. Nörolojide konsültasyonlar önemli bir konu olup, bu hizmetin incelikleri, aksayan yönleri ve konsültasyon verimini etkileyen faktörler tüm bilim dallarýnca incelenerek deðerlendirilmelidir.

The purpose of this study was to determine the reasons and frequency of consultations asked for patients hospitalized in clinics other than neurology and the index of productivity of these consultations according to criteria which was originally formed by us. A form was organized for each patient containing social and demographic data, diagnosis, reason for consultation, the date of hospitalization, the date of consultation, neurological diagnosis or prodiagnosis and the clinical course. Neurological consultations were asked for 172 out of 1560 patients who were hospitalized and each one was examined by a neurologist. The frequency of neurology consultations were foundto be 11%. It was determined that this frequency was highest in internal medicine, infectious disease and otorhinolaryngology and the reason for a consultation was mostly a proxysmal disorders such as headache, paresthesia and vertigo . The index of productivity was higher in internal medicine branches than surgical branches. The frequency of consultations and index of productivity were found to be very low in surgical branches except otorhinolaryngology, orthopedics and ophthalmology. These results were thought to be due to utilization of more radical methods and shorter hospitalization periods in surgical branches. Consulting for a neurological examination is important and factors affecting efficiency must be carefully considered by all clinical branches.

Nörobruselloz, sistemik brusellozun santral ve/veya periferik sinir sistemine lokalize bir formudur. Birçok nörolojik hastalýðý taklit ettiði bilinmektedir. Bu makalede nörobrusellozun nadir rastlanan klinik formu olmasý nedeniyle genç bir geçici iskemik atak olgusu sunulmuþtur.

Neurobrucellosis is a localised form of brucellosis in peripheral and/or central nervous system. It may mimic various neurological diseases. We report a case with transient ischemic attacks as a rare clinical form of neurobrucellosis.

Restless Legs Sendromu (Ekbom sendromu) bacaklarda ve nadiren kollarda istirahatte ortaya çýkýp hareketle azalan, rahatsýz edici derin parestezilerle karakterize, insomniye yol açan bir hastalýktýr. Tablo sýklýkla uykuda periodik bacak hareketleri ile birliktedir. Bir çok hastada altta yatan baþka hastalýk bulunmamakla birlikte, semptomatik tedavi baþlanmadan önce, tedavi imkaný olan etyolojik faktörlerin mutlaka araþtýrýlmasý gerekir. Bu makalede sadece demir replasmaný ile günler içinde asemptomatik hale gelmiþ üç restless legs sendromu olgusu sunulmuþtur.

Restless legs syndrome is a disorder characterized by uncomfortable deep paresthesias in the legs and occasionally in the arms which occur at rest and releave by movement. It is a frequent cause of insomnia and most often occurs in association with periodic leg movements in sleep. Although this syndrome is idiopathic in most patients, potential etiologic factors should be investigated before beginning symptomatic therapy. Here we report three patients with symptoms of restless legs syndrome who became asymptomatic after iron substitution.

Literatürde oldukça düþük insidansta bildirilen karotid-oftalmik anevrizmalar paraklinoid bölgede internal karotid arterin C2 ve distal C3 kýsmýndan oluþurlar. Optik sinir kompresyonuna baðlý geliþen progresif visuel kayýp ve subaraknoid kanama ön plandaki klinik bulgularý oluþturur. Bilgisayarlý beyin tomografisi (BET) ve anjiografide unrupture büyük karotid-oftalmik segment anevrizmasý saptanan sol gözde progresif görme kaybý ve periorbital aðrýsý olan bir kadýn olgu sunularak literatür ýþýðýnda tartýþýlmýþtýr.

Carotid-ophthalmic ( or paraclinoid ) aneurysms which arise from the C2 and distal C3 portions of the internal carotid artery are rarely reported in the literature. Initial presenting symptoms are either subarachnoid hemorrhage or progressive visual loss due to the optic nerve compression. A female patient with progressive visual loss and periorbital pain in her left eye is presented with her CT and angiography finding demonstrating unruptured large carotid-ophthalmic segment aneurysm.