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  Clinical And Electropbysiologic Effects Of Atropine And Diazepam On Experımental Epilepsy Induced By Lithıum-Pilocarpine [Turk J Neurol]
Turk J Neurol. 1995; 1(4): 190-194

Clinical And Electropbysiologic Effects Of Atropine And Diazepam On Experımental Epilepsy Induced By Lithıum-Pilocarpine

İbrahim BORA1, Suat ÇELİK2, Mustafa BAKAR1, Sibel GÜRÜN3, Sadık SADIKOĞLU1, Faruk TURAN1, Mehmet ZARİFOĞLU1, Çiğdem UÇKUNKAYA4, İsmail Hakkı ULUS3, Erhan OĞUL1
1Uludağ Üniversitesi Tıp Fakültesi Nöroloji AD, Bursa
2Uludağ Üniversitesi Tıp Fakültesi Nöroşirurji AD, Bursa
3Uludağ Üniversitesi Tıp Fakültesi Farmakoloji AD, Bursa
4Bursa Devlet Hastanesi

In this study status epilepticus was induced in rats by administration of lithium chloridefollowed 24 hours later by injection of pilocarpine. Administration of atropine which a ismuscarinic-cholinergic receptor antagonist, before pilocarpine arrested generalised statusepilepticus, except limbic seizures. EEG displayed clear improvement. Administration ofdiazepam prior to pilocarpine blocked seizure and EEG activity. The results of this studysuggest that cholinergic mechanisms play an important role in lithium pilaocarpineepileptogenesis

Keywords: Atropine, Experimental epilepsy, diazepam, lithium-pilocarpine, status epilepticus.


İbrahim BORA, Suat ÇELİK, Mustafa BAKAR, Sibel GÜRÜN, Sadık SADIKOĞLU, Faruk TURAN, Mehmet ZARİFOĞLU, Çiğdem UÇKUNKAYA, İsmail Hakkı ULUS, Erhan OĞUL. Clinical And Electropbysiologic Effects Of Atropine And Diazepam On Experımental Epilepsy Induced By Lithıum-Pilocarpine. Turk J Neurol. 1995; 1(4): 190-194

Corresponding Author: İbrahim BORA


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