Clinical And Electropbysiologic Effects Of Atropine And Diazepam On Exper�mental Epilepsy Induced By Lith�um-Pilocarpine

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Volume : 28 Issue : 2 Year : 2022

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Turkish Journal of Neurology Indexed By

Clinical And Electropbysiologic Effects Of Atropine And Diazepam On Exper�mental Epilepsy Induced By Lith�um-Pilocarpine [Turk J Neurol]

Turk J Neurol. 1995; 1(4): 190-194

Clinical And Electropbysiologic Effects Of Atropine And Diazepam On Exper�mental Epilepsy Induced By Lith�um-Pilocarpine

�brahim BORA¹, Suat �EL�K², Mustafa BAKAR¹, Sibel G�R�N³, Sad�k SADIKO�LU¹, Faruk TURAN¹, Mehmet ZAR�FO�LU¹, �i�dem U�KUNKAYA⁴, �smail Hakk� ULUS³, Erhan O�UL¹
¹Uluda� �niversitesi T�p Fak�ltesi N�roloji AD, Bursa
²Uluda� �niversitesi T�p Fak�ltesi N�ro�irurji AD, Bursa
³Uluda� �niversitesi T�p Fak�ltesi Farmakoloji AD, Bursa
⁴Bursa Devlet Hastanesi

In this study status epilepticus was induced in rats by administration of lithium chloridefollowed 24 hours later by injection of pilocarpine. Administration of atropine which a ismuscarinic-cholinergic receptor antagonist, before pilocarpine arrested generalised statusepilepticus, except limbic seizures. EEG displayed clear improvement. Administration ofdiazepam prior to pilocarpine blocked seizure and EEG activity. The results of this studysuggest that cholinergic mechanisms play an important role in lithium pilaocarpineepileptogenesis

Keywords: Atropine, Experimental epilepsy, diazepam, lithium-pilocarpine, status epilepticus.

�brahim BORA, Suat �EL�K, Mustafa BAKAR, Sibel G�R�N, Sad�k SADIKO�LU, Faruk TURAN, Mehmet ZAR�FO�LU, �i�dem U�KUNKAYA, �smail Hakk� ULUS, Erhan O�UL. Clinical And Electropbysiologic Effects Of Atropine And Diazepam On Exper�mental Epilepsy Induced By Lith�um-Pilocarpine. Turk J Neurol. 1995; 1(4): 190-194

Corresponding Author: �brahim BORA

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