The Neuroimmunologic Approach to Tension Type Headache and Migraine

OBJECTIVE: The immunologic studies that investigate pat-
hogenesis of tension type headache are going on. Although the studies
about interleukines, TNF-α, IgG, complemans and NO were reported,
the parameters like MIP-1α, RANTES, eotaxin and endotelin-1 (ET-1) ha-
ven’t been studied yet
METHODS: The aim of our study was investigated the role of TNF-α, IL-
6, NO and MIP-1α, RANTES, eotaxin and ET-1 at the pathogenesis of
tension type headache and compared these parameters with migraine
patients.
RESULTS: The level of these parameters were measured
during headache period and headache free period at 72 patients with
tension type headache (32 of them episodic and 40 of them chronic
type), 58 patients with migraine (30 of them with aura and 28 of them
without aura) and 30 healthy patients.
CONCLUSION: It was founded that TNF-α, IL-6, NO, MIP-1α, RANTES, eotaxin
and ET-1 levels were increased at the patients with tension type headac-
he and migraine during the headache period when was compared with
control group and the patients in headache free period. These results can be thought that they are similarity in ne-
uroimmunologic reactions between tension type and and MIP-1α,
RANTES, eotaxin and ET-1 could be have a role in pathogenesis of ten-
sion type headache.