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Turkish Journal of Neurology Indexed By
  Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis [Turk J Neurol]
Turk J Neurol. 2021; 27(4): 390-393 | DOI: 10.4274/tnd.2021.70962  

Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis

Alp Sarıteke1, İrem Fatma Uludağ1, Berk Özyılmaz2, Yaşar Zorlu1, Ufuk Şener1, Figen Tokuçoğlu1
1University of Health Sciences Turkey, Izmir Tepecik Training and Research Hospital, Clinic of Neurology, Izmir, Turkey
2University of Health Sciences Turkey, Izmir Tepecik Training and Research Hospital, Clinic of Genetic Diseases, Izmir, Turkey

Objective: We aimed to determine the association between a polymorphism in the promoter region of the IL-1beta gene resulting in enhanced gene transcription and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS).
Materials and Methods: The frequency of a single nucleotide polymorphism (SNP) that results in a C>T transition of 511 base pairs that are five prime to the transcription start site of the IL-1beta gene in a group of 21 patients with TLE+HS, 21 patients with temporal lobe epilepsy without hippocampal sclerosis (TLE-HS), and 23 healthy volunteers.
Results: The frequency of the -511T allele was 11/21 in the TLE-HS group, 13/21 in the TLE+HS group, and 12/23 in the control group. Chi-square analysis of genotype and allele distribution showed no significant difference between the patients in TLE+HS, TLE-HS, and control group
Conclusion: There was no association between the -511/C>T SNP variation and TLE+HS.

Keywords: IL-1beta, temporal lobe epilepsy, hippocampal sclerosis, epilepsy, genetics


Alp Sarıteke, İrem Fatma Uludağ, Berk Özyılmaz, Yaşar Zorlu, Ufuk Şener, Figen Tokuçoğlu. Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis. Turk J Neurol. 2021; 27(4): 390-393

Corresponding Author: İrem Fatma Uludağ, Türkiye


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