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  Anticonvulsive Effect Of Mk-801 On Experimental Epileptic Model Induced By Kainic Acid In Rats [Turk J Neurol]
Turk J Neurol. 1995; 1(4): 195-199

Anticonvulsive Effect Of Mk-801 On Experimental Epileptic Model Induced By Kainic Acid In Rats

İbrahim BORA1, Oya ULUSAN2, Mustafa BAKAR1, Sibel GÜRÜN3, Mehmet ZARİFOĞLU1, Faruk TURAN1, İsmail Hakkı ULUS3, Erhan OĞUL1
1Uludağ Üniversitesi Tıp Fakültesi Nöroloji AD, Bursa
2Uludağ Üniversitesi Tıp Fakültesi Nöroşirurji AD, Bursa
3Uludağ Üniversitesi Tıp Fakültesi Farmakoloji AD, Bursa

Synaptic transmission in the central nervous system ise supplied by chemical agents known as neurotransmitters. Kainic acid is a strong neuroexcitatory agent in brain which increase releases excitatory amino acids such as glutamate and aspartate. MK-801 is an anticonvulsant agent which reduces the effects of excitatory amino acids. Our aim was to investigate antiepileptic effects of MK-801 on seizures induced by kainic acid. In this study 45 rats were divided into three groups. Kainic acid wase given in the hipocampus. The first group was given kainic acid+saline, the second group was given kainic acid+MK-801 (as intraperitoneal) and the third group was served as the control. EEG recording and clinical seizure observation had done before and after these procedures and all scores were recorded. In the study and control groups it was establis hed statistically important differences between seizure starting period, clinical seizures and EEG scores. In this study, we concluded that MK-801 is moderately effective on clinical and electrbphysiolgicseizure activities induced by kainic acid in rats.

Keywords: Experimental epilepsy, Kainic acid, MK-801.


İbrahim BORA, Oya ULUSAN, Mustafa BAKAR, Sibel GÜRÜN, Mehmet ZARİFOĞLU, Faruk TURAN, İsmail Hakkı ULUS, Erhan OĞUL. Anticonvulsive Effect Of Mk-801 On Experimental Epileptic Model Induced By Kainic Acid In Rats. Turk J Neurol. 1995; 1(4): 195-199

Corresponding Author: İbrahim BORA


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