Progressive Multifocal Leucoencephalopathy: Clinical, Neuroradiologicaland Neuropathological Findings

Progressive Multifocal Leucoencephalopathy (PML) is a rare disease caused by viruses of the papovavirus family and is charaeterised by progressive, multifocal areas of demyelinisation involving the subcortical white matter, cerebellum and brainstem. The disease is usually seen in patients with a defect in cellular immunity, like AIDS, but infrequently no etiologic cause can be demonstrated. We report a case demonstratingthe typical clinical, radiological and histopathological features of PML in whom no etiologic cause could be identified.