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Turkish Journal of Neurology Indexed By
  Do Plasma Nitric Oxide Levels Have an Impact on Unprovoked Migraine Attacks? [Turk J Neurol]
Turk J Neurol. 2023; 29(3): 216-219 | DOI: 10.4274/tnd.2023.51447  

Do Plasma Nitric Oxide Levels Have an Impact on Unprovoked Migraine Attacks?

Yasemin Ekmekyapar Fırat1, Saniye Koç Ada2, Emine Kılıçparlar Cengiz3, Abdurrahman Neyal4, Mustafa Baki Çekmen2, Ayşe Münife Neyal1
1Department Of Neurology, Sanko University School Of Medicine, Gaziantep, Turkey
2Department Of Medical Biochemistry, İstanbul Medeniyet University School Of Medicine, İstanbul, Turkey
3Department Of Neurology, Dr. Ersin Arslan Education And Research Hospital, Gaziantep, Turkey
4Department Of Neurology, Gi̇btü University School Of Medicine, Gaziantep, Turkey

Objective: Provocation studies on the role of nitric oxide (NO) in the pathophysiology of migraine have long been conducted and provide important information. Although there are many provocation studies in the literature, there are fewer publications on the role of NO in spontaneous migraine attacks. In this study, we aimed to compare the serum NO levels during unprovoked attacks in patients with migraine using the values in the interictal period and the results of the control group.
Materials and Methods: Thirty migraine patients were evaluated for plasma NO levels during the natural course of unprovoked attacks and in the interictal period. They were also compared with the results of 25 healthy controls.
Results: The mean plasma NO levels were 20.99 ± 4.93 μmol/l during migraine attacks, 25.97 ± 9.83 μmol/l between attacks and 23.22 ± 7.57 μmol/l in the control group. According to these results, the mean plasma NO levels were significantly lower in migraineurs during attacks compared to the non-attack period (P = 0.025), but there was no significant difference with controls (P = 0.212 and P = 0.247, respectively).
Conclusion: To evaluate whether NO has an effect on the natural history of migraine attacks, more spontaneous attack studies involving methods other than measuring serum levels are needed.

Keywords: Migraine, nitric oxide, spontaneous attack

Yasemin Ekmekyapar Fırat, Saniye Koç Ada, Emine Kılıçparlar Cengiz, Abdurrahman Neyal, Mustafa Baki Çekmen, Ayşe Münife Neyal. Do Plasma Nitric Oxide Levels Have an Impact on Unprovoked Migraine Attacks?. Turk J Neurol. 2023; 29(3): 216-219

Corresponding Author: Yasemin Ekmekyapar Fırat, Türkiye

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