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Turkish Journal of Neurology Indexed By
  Basic Concept in Neuroimmunology [Turk J Neurol]
Turk J Neurol. 1997; 3(3): 83-97

Basic Concept in Neuroimmunology

Egemen İDİMAN
Dokuz Eylül Ü.T.F. Nöroloji Anabilim Dalı, İzmir

Immun system occurs from peripheral organs and celular elements includiııg T cells, B cells, mononuclear phagocytes, natural killer (NK) cells. The events that lead ta autoimmune disease are not clear. The immune mediated neurologic diseases probably occur the following sequential steps. 1- The breaking of the self tolerance, 2- The processing of the antigen by the antigen presenting cell and antigen recognition by the T-cell receptor complex. 3- Migration of activated T cells from the circulation to the nervous system via adhesion molecules, 4- Tissue injury. Cytokines and lymphokines secreted by the activated T cells and macrophages play a major role as enhancers of the immune response.

Keywords: Immune system, lmmune mediated neurological diseases


Egemen İDİMAN. Basic Concept in Neuroimmunology. Turk J Neurol. 1997; 3(3): 83-97

Corresponding Author: Egemen İDİMAN


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