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  Transient Encephalopathy with A Single Dose of Oral Metronidazole: A Case Report [Turk J Neurol]
Turk J Neurol. 2021; 27(1): 82-84 | DOI: 10.4274/tnd.2020.47154  

Transient Encephalopathy with A Single Dose of Oral Metronidazole: A Case Report

Erman Altunışık1, Şebnem Zeynep Eke Kurt2
1Adiyaman University Training and Research Hospital, Clinic of Neurology, Adiyaman, Turkey
2Adiyaman University Training and Research Hospital, Clinic of Emergency Medicine, Adiyaman, Turkey

Metronidazole (MNZ) is an antibacterial agent widely used in the treatment of anaerobic and protozoal infections, easily penetrating the cerebrospinal fluid and central nervous system. MNZ is well-tolerated, but it can also cause serious neurologic adverse effects such as peripheral neuropathy, ataxia, dysarthria, convulsion and encephalopathy. MNZ-induced encephalopathy (MIE) is a rare adverse effect. Magnetic resonance imaging and electroencephalography are helpful methods in the diagnosis of the disease. The mechanism of MIE has not been clearly elucidated. Usually, it is completely cured by drug discontinuation. In this report, a reversible encephalopathy developing in a male patient after receiving a single dose of oral MNZ is presented.

Keywords: Metronidazole, encephalopathy, electroencephalography


Erman Altunışık, Şebnem Zeynep Eke Kurt. Transient Encephalopathy with A Single Dose of Oral Metronidazole: A Case Report. Turk J Neurol. 2021; 27(1): 82-84

Corresponding Author: Erman Altunışık, Türkiye


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