Restless Leg Syndrome and Its Relationship with Parkinson’s Disease

OBJECTIVE: Restless legs syndrome (RLS) and Parkinson’s
disease (PD) exhibit striking similarities in impairment of central
dopaminergic transmission and response to dopamine replacement
strategies. The main question is whether RLS and PD are associated
disorders sharing the common pathophsiology and genetic vulnerability
or RLS resulted from nighttime motor disability related to disease itself
or treatment or only a comorbidity. The links and also similarities and
differences between RLS and PD in respect to epidemiology, clinical
features, pathophysiology, neuropharmacology, neurophysiology,
neuroimaging, iron metabolism and genetics were reported below.
METHODS:
RESULTS:
CONCLUSION: