Restless Leg Syndrome and Its Relationship with Parkinson’s DiseaseDerya Kaynak, Gülçin GülçinDepartment Of Neurology, İstanbul University, Cerrahpasa Faculty Of Medicine, İstanbul, Turkey
OBJECTIVE: Restless legs syndrome (RLS) and Parkinson’s disease (PD) exhibit striking similarities in impairment of central dopaminergic transmission and response to dopamine replacement strategies. The main question is whether RLS and PD are associated disorders sharing the common pathophsiology and genetic vulnerability or RLS resulted from nighttime motor disability related to disease itself or treatment or only a comorbidity. The links and also similarities and differences between RLS and PD in respect to epidemiology, clinical features, pathophysiology, neuropharmacology, neurophysiology, neuroimaging, iron metabolism and genetics were reported below. METHODS: RESULTS: CONCLUSION:
Keywords: Restless legs syndrome, Parkinson’s disease
Derya Kaynak, Gülçin Gülçin. Restless Leg Syndrome and Its Relationship with Parkinson’s Disease. Turk J Neurol. 2006; 12(2): 121-128
Corresponding Author: Derya Kaynak, Türkiye |
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