Prevalence Of Thrombophilic Mutations In Ischemic Stroke Patients In Isparta, Turkey

OBJECTIVE: The present study aimed to investigate whether the frequency of factor V, methylenetetrahydrofolate reductase (MTHFR), prothrombin, β-fibrinogen gene mutations, and human platelet alloantigens (HPA), plasminogen activator inhibitor 1 (PAI1), apolipoprotein E (APOE), and angiotensin converting enzyme (ACE) gene polymorphisms in stroke patients is higher than that in normal individuals.
METHODS: Two hundred twelve patients with cerebral infarction and 238 individuals of similar age and gender with no history of stroke were included. Demographics and risk factors for cerebrovascular disease of all individuals were determined. Biochemical parameters were analyzed in serum, and electrocardiography was performed. Factor V, MTHFR, prothrombin, β-fibrinogen mutations and HPA, PAI, APOE, and ACE polymorphisms were investigated. Data were analyzed with SPSS 15.0 software using descriptive statistics, chi-square, independent two-group t-test, and logistic regression tests. Statistically significant differences in independent variables were further analyzed by logistic regression. p < 0.05 was considered statistically significant.
RESULTS: HPA, PAI, APO, and ACE polymorphism frequency was not significantly different between the stroke and control groups. Factor V H1299R, factor V Leiden, and β fibrinogen -455GA mutation frequency was significantly higher in the stroke than the control group by the chi-square test, but not by logistic regression analysis.
CONCLUSION: Stroke etiopathogenesis is multifactorial, and prothrombin gene mutations increase the impact of existing risk factors when other risk factors are considered.